ArticleJournal of molecular evolution2019
Perspectives on the Origin of Biological Homochirality on Earth.
Article in Journal of molecular evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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10 citing papers in PubMed.
- Predicting and Rationalizing Piezoelectricity in Racemic Bioorganic Molecular Crystals.Angewandte Chemie (International ed. in English) · 2026Article
- D- and L-lactate consumers are taxonomically, biochemically, and energetically different.ISME communications · 2026Article
- Origin of homochirality in terrestrial biology.Journal of biosciences · 2025Article
- Mechanism of Chiral-Selective Aminoacylation of an RNA Minihelix Explored by QM/MM Free-Energy Simulations.Life (Basel, Switzerland) · 2023Article
- Acquisition of Dual Ribozyme-Functions in Nonfunctional Short Hairpin RNAs through Kissing-Loop Interactions.Life (Basel, Switzerland) · 2022Article
- Diastereomeric dinickel(II) complexes with non-innocent bis(octaazamacrocyclic) ligands: isomerization, spectroelectrochemistry, DFT calculations and use in catalytic oxidation of cyclohexane.Dalton transactions (Cambridge, England : 2003) · 2022Article
- Effects of shape and solute-solvent compatibility on the efficacy of chirality transfer: Nanoshapes in nematics.Science advances · 2022Article
- The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions.Journal of the American Chemical Society · 2021Article
- G:U-Independent RNA Minihelix Aminoacylation by Nanoarchaeum equitans Alanyl-tRNA Synthetase: An Insight into the Evolution of Aminoacyl-tRNA Synthetases.Journal of molecular evolution · 2020Article
- RNA Aptamers for a tRNA-Binding Protein fromLife (Basel, Switzerland) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
The origin of biological homochirality on Earth has been an important unresolved issue in the field of molecular evolution and many hypotheses have been proposed to explain this. The most prevailing view may be that of astrobiologists, in that a slight enantiomeric excess of L-amino acids in meteorites can account for the origin. However, the view ignores two important factors: amino acid racemization, and the evolution and continuity of biological systems on Earth. Therefore, on the basis of these two standpoints, the plausibility of the hypothesis that chiral-selective tRNA aminoacylation could have led to crucial homochiral protein biosynthesis should be emphasized. Recent molecular dynamic simulations have clearly elucidated the mechanisms of enantiomer-specific aminoacylation. These studies strengthen the possibility that the hypothesized chiral selection of amino acids in biological systems actually occurred at the molecular level. It is significant to raise the points because the topic so far has tended to be expressed unclearly and ambiguously and also handled as such owing to its very nature.
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