Evidence map›Paper›PMID 31253976›Full record

ArticleNature genetics2019

Mutagenesis-based protein structure determination.

Melissa Chiasson, Douglas M Fowler

Abstract read
PubMed Publisher
In one paragraph

Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Not Enough Natural Data? Sequence and Ye Shall Find.Frontiers in molecular biosciences · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melissa ChiassonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Douglas M FowlerDepartment of Genome Sciences, University of Washington, Seattle, WA, USA. dfowler@uw.edu.ORCID http://orcid.org/0000-0001-7614-1713

Funding

Technology to understand genetic variant effects in contextRM1HG010461 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Bruce Colston Trapnell · 2019 to 2026
$18.9M
F-CAP: Functionalization of Variants in Clinically Actionable PharmacogenesR24GM115277 · NIGMS · UNIVERSITY OF WASHINGTON · PI FOWLER, DOUGLAS M, RETTIE, ALLAN EDWARD · 2015 to 2017
$2.2M
Comprehensive, context-aware, functional analysis of Cytochrome P450 variantsR01GM132162 · NIGMS · UNIVERSITY OF WASHINGTON · PI DUNHAM, MAITREYA J, FOWLER, DOUGLAS M · 2019 to 2022
$2.1M
NHGRI NIH HHS RM1 HG010461NIGMS NIH HHS R24 GM115277
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutagenesisProtein ConformationComputer SimulationCrystallography, X-RayHumansProteinsProteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.