ArticleScientific reports2019
Varroa destructor parasitism has a greater effect on proteome changes than the deformed wing virus and activates TGF-β signaling pathways.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 58 citations in OpenAlex.
- Gut plasma membrane proteomes of adults and larvae of the European honey bee, Apis mellifera.Scientific reports · 2025Article
- Multi-Genome-Wide association studies provide new insights into the genetic architecture of Varroa resistance in honeybees.BMC genomics · 2025Article
- Parasitic Mites of Honey Bees (Apis Spp.): A Detailed Review of Varroa destructor in Parasitism, Pathogen Transmission and its Management.Acta parasitologica · 2025Review
- Remodeling of Cellular Respiration and Insulin Signaling Are Part of a Shared Stress Response in Divergent Bee Species.Insects · 2025Article
- Review
- Effects of Deformed Wing Virus-Targeting dsRNA on Viral Loads in Bees Parasitised and Non-Parasitised byViruses · 2023Article
- Article
- A phylogenomic and comparative genomic analysis of Commensalibacter, a versatile insect symbiont.Animal microbiome · 2023Article
- Multi-tiered analyses of honey bees that resist or succumb to parasitic mites and viruses.BMC genomics · 2021Article
- Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae).BMC genomics · 2021Article
- Article
- Effects of Deformed Wing Virus Infection on Expressions of Immune- and Apoptosis-Related Genes in Western Honeybees (Insects · 2021Article
- Juvenile hormone pathway in honey bee larvae: A source of possible signal molecules for the reproductive behavior ofEcology and evolution · 2021Article
- Article
- Varroa destructor: how does it harm Apis mellifera honey bees and what can be done about it?Emerging topics in life sciences · 2020Review
- Identification of Immune Response to Sacbrood Virus Infection inFrontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honeybee workers undergo metamorphosis in capped cells for approximately 13 days before adult emergence. During the same period, Varroa mites prick the defenseless host many times. We sought to identify proteome differences between emerging Varroa-parasitized and parasite-free honeybees showing the presence or absence of clinical signs of deformed wing virus (DWV) in the capped cells. A label-free proteomic analysis utilizing nanoLC coupled with an Orbitrap Fusion Tribrid mass spectrometer provided a quantitative comparison of 2316 protein hits. Redundancy analysis (RDA) showed that the combination of Varroa parasitism and DWV clinical signs caused proteome changes that occurred in the same direction as those of Varroa alone and were approximately two-fold higher. Furthermore, proteome changes associated with DWV signs alone were positioned above Varroa in the RDA. Multiple markers indicate that Varroa activates TGF-β-induced pathways to suppress wound healing and the immune response and that the collective action of stressors intensifies these effects. Furthermore, we indicate JAK/STAT hyperactivation, p53-BCL-6 feedback loop disruption, Wnt pathway activation, Wnt/Hippo crosstalk disruption, and NF-κB and JAK/STAT signaling conflict in the Varroa-honeybee-DWV interaction. These results illustrate the higher effect of Varroa than of DWV at the time of emergence. Markers for future research are provided.
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