ArticleScientific reports2019
Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Automated behavioral segmentation and markerless pose tracking of mice during spaceflight.bioRxiv : the preprint server for biology · 2026Article
- MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo.Journal of cachexia, sarcopenia and muscle · 2026Article
- Proton radiation impairs mechanotransduction in C2C12 myoblasts.NPJ microgravity · 2026Article
- 0.33Science advances · 2026Article
- Long non-coding RNAs Kcnq1ot1 and Lncpint are involved in skeletal muscle atrophy induced by the space exposome.The Journal of physiology · 2025Article
- Role of cardiolipin in skeletal muscle function and its therapeutic implications.Cell communication and signaling : CCS · 2025Review
- Muscle Disuse Atrophy.Advances in experimental medicine and biology · 2025Review
- Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being.Nutrition & metabolism · 2024Review
- Factors, mechanisms and improvement methods of muscle strength loss.Frontiers in cell and developmental biology · 2024Review
- Inflammation and Fatty Infiltration Correlates with Rotator Cuff Muscle Atrophy in Hypercholesterolemic Yucatan Microswine.Journal of orthopaedics and sports medicine · 2024Article
- Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice.NPJ microgravity · 2023Article
- Article
- Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.Communications biology · 2023Article
- Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice.Communications biology · 2023Article
- Review
- Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice.NPJ microgravity · 2023Article
- Murine Models of Tenotomy-Induced Mechanical Overloading and Tail-Suspension-Induced Mechanical Unloading.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Cholesterol: An Important Determinant of Muscle Atrophy in Astronauts.Journal of biotechnology and biomedicine · 2023Article
- Review
- Signatures of muscle disuse in spaceflight and bed rest revealed by single muscle fiber proteomics.PNAS nexus · 2022Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal muscle; MuRF1 null (KO) mice have shown protection in ground-based models of muscle atrophy. In contrast, MuRF1 KO mice subjected to 21 days of microgravity on the International Space Station (ISS) were not protected from muscle atrophy. In a time course experiment microgravity-induced muscle loss on the ISS showed MuRF1 gene expression was not upregulated. A comparison of the soleus transcriptome profiles between spaceflight and a publicly available data set for hindlimb suspension, a claimed surrogate model of microgravity, showed only marginal commonalities between the models. These findings demonstrate spaceflight induced atrophy is unique, and that understanding of effects of space requires study situated beyond the Earth's mesosphere.
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