ArticleNature communications2019
Site-specific cleavage of bacterial MucD by secreted proteases mediates antibacterial resistance in Arabidopsis.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The front line of defence: a meta-analysis of apoplastic proteases in plant immunity.Journal of experimental botany · 2021Pooled it
- Apoplast Engineering Unveiled: Multi-Target Strategies to Disarm Pathogens and Elevate Global Food Security.Plant, cell & environment · 2026Review
- Genomic and metabolomics analysis: unlocking the biocontrol mechanism of Trichoderma virilente Z53 against anthracnose in Pleione yunnanensis.BMC plant biology · 2026Article
- A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hacking the immune system: plant immune protease engineering for crop protection.Journal of experimental botany · 2025Review
- Four guidelines to identify bona fide protease-substrate pairs.Journal of experimental botany · 2025Review
- The OsAP4-OsCATA/OsCATC Regulatory Module Orchestrates Drought Stress Adaptation in Rice Seedlings Through ROS Scavenging.Plants (Basel, Switzerland) · 2025Article
- Apoplastic proteomic reveals Colletotrichum fructicola effector CfXyn11A recognized by tobacco and suppressed by pear in the apoplast.Molecular horticulture · 2025Article
- An Activity-Based Proteomics with Two-Dimensional Polyacrylamide Gel Electrophoresis (2D-PAGE) for Identifying Target Proteases inBio-protocol · 2025Article
- Article
- Proteolysis in plant immunity.The Plant cell · 2024Review
- Pull the fuzes: Processing protein precursors to generate apoplastic danger signals for triggering plant immunity.Plant communications · 2024Review
- The chromosome-level genome of the submerged plant Cryptocoryne crispatula provides insights into the terrestrial-freshwater transition in Araceae.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Commensal lifestyle regulated by a negative feedback loop between Arabidopsis ROS and the bacterial T2SS.Nature communications · 2024Article
- How plants manage pathogen infection.EMBO reports · 2024Review
- Solanum lycopersicum heme-binding protein 2 as a potent antimicrobial weapon against plant pathogens.Scientific reports · 2023Article
- Defense against phytopathogens relies on efficient antimicrobial protein secretion mediated by the microtubule-binding protein TGNap1.Nature communications · 2023Article
- Biophysical and proteomic analyses ofmBio · 2023Article
- Mechanisms controlling plant proteases and their substrates.Cell death and differentiation · 2023Review
- A Proteomics Insight into Advancements in the Rice-Microbe Interaction.Plants (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant innate immunity restricts growth of bacterial pathogens that threaten global food security. However, the mechanisms by which plant immunity suppresses bacterial growth remain enigmatic. Here we show that Arabidopsis thaliana secreted aspartic protease 1 and 2 (SAP1 and SAP2) cleave the evolutionarily conserved bacterial protein MucD to redundantly inhibit the growth of the bacterial pathogen Pseudomonas syringae. Antibacterial activity of SAP1 requires its protease activity in planta and in vitro. Plants overexpressing SAP1 exhibit enhanced MucD cleavage and resistance but incur no penalties in growth and reproduction, while sap1 sap2 double mutant plants exhibit compromised MucD cleavage and resistance against P. syringae. P. syringae lacking mucD shows compromised growth in planta and in vitro. Notably, growth of ΔmucD complemented with the non-cleavable MucD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.