ArticleNature communications2019
Chromatin organization in the female mouse brain fluctuates across the oestrous cycle.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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Who cites it
63 citing papers in PubMed, 113 citations in OpenAlex.
- Article
- Gestational choline supplementation regulates hippocampal granule neuron development and emotion-like behavior.Communications biology · 2026Article
- Single-cell map of the female brain across reproductive transitions.bioRxiv : the preprint server for biology · 2026Article
- Acetate enhances long-term memory in female mice by sex-, context-, and brain region-specific epigenetic and transcriptional remodeling.Science signaling · 2026Article
- The lateral septum orchestrates state-dependent modulation of associative threat memory dynamics across the ovarian hormone cycle.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal tissue mechanics are sensitive to fluctuations in oestrogen across the rat oestrous cycle.Brain communications · 2026Article
- Leveraging high-resolution brain imaging and (epi)genomic approaches to improve women's mental health.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Microglial interferon signaling and Aβ plaque pathology are enhanced in female 5xFAD Alzheimer's disease mice, independent of estrous cycle stage.Journal of neuroinflammation · 2025Article
- Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour.Nature communications · 2025Article
- Writing the Engram: Epigenetic Mechanisms of Memory Allocation.Journal of neurochemistry · 2025Review
- Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions.Nature communications · 2025Article
- Rethinking women's brain health.Nature reviews. Neuroscience · 2025Article
- Early positive tactile stimulation reverses the increase of anxiety and decrease of sociality induced by early chronic mechanical pain in mandarin voles.Integrative zoology · 2025Article
- The effects of pharmacologic estradiol on anxiety-related behavior in adolescent and adult female mice.Physiology & behavior · 2025Article
- Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights From (Female) Mice and (Wo)men.Biological psychiatry · 2025Article
- The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice.Hormones and behavior · 2025Article
- Review
- Advancing 3Rs: The Mouse Estrus Detector (MED) as a Low-Stress, Painless, and Efficient Tool for Estrus Determination in Mice.International journal of molecular sciences · 2024Article
- Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures.Cell genomics · 2024Article
- Androgen regulation of behavioral stress responses and the hypothalamic-pituitary-adrenal axis.Hormones and behavior · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Male and female brains differ significantly in both health and disease, and yet the female brain has been understudied. Sex-hormone fluctuations make the female brain particularly dynamic and are likely to confer female-specific risks for neuropsychiatric disorders. The molecular mechanisms underlying the dynamic nature of the female brain structure and function are unknown. Here we show that neuronal chromatin organization in the female ventral hippocampus of mouse fluctuates with the oestrous cycle. We find chromatin organizational changes associated with the transcriptional activity of genes important for neuronal function and behaviour. We link these chromatin dynamics to variation in anxiety-related behaviour and brain structure. Our findings implicate an immediate-early gene product, Egr1, as part of the mechanism mediating oestrous cycle-dependent chromatin and transcriptional changes. This study reveals extreme, sex-specific dynamism of the neuronal epigenome, and establishes a foundation for the development of sex-specific treatments for disorders such as anxiety and depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.