ArticleNature communications2019
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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44citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors.Scientific reports · 2021Pooled it
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- IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma.Nature immunology · 2026Article
- MHC class I on target cells regulates CD4Nature immunology · 2026Article
- STING activation induces polarized cytokine secretion of IFN-β and IL-17A promoting photoreceptor death and choroidal disruption in age-related macular degeneration.Cell death & disease · 2026Article
- Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients.Communications biology · 2026Article
- Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer.bioRxiv : the preprint server for biology · 2025Article
- The immunomodulatory p43 secreted protein of Trichuris whipworm parasites is a lipid carrier that binds signalling lipids and precursors.Scientific reports · 2025Article
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- Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions.Cellular and molecular life sciences : CMLS · 2025Article
- Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis.PLoS pathogens · 2024Article
- Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis.Nature immunology · 2024Article
- JAK-STAT signaling maintains homeostasis in T cells and macrophages.Nature immunology · 2024Article
- Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy.The Journal of clinical investigation · 2024Article
- A Combination of Four Nuclear Targeted Effectors ProtectsbioRxiv : the preprint server for biology · 2023Article
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- Comparative transcriptome analysis provides insight into the molecular targets and signaling pathways of deer TGF-1 regulating chondrocytes proliferation and differentiation.Molecular biology reports · 2023Article
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- Exploring the shared molecular mechanisms between systemic lupus erythematosus and primary Sjögren's syndrome based on integrated bioinformatics and single-cell RNA-seq analysis.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
35 authors at 11 institutions in 3 countries.
Akul SinghaniaLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0002-6941-3618
Christine M GrahamLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, NW1 1AT, UK.
Leona GabryšováLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0003-3529-1306
Lúcia Moreira-TeixeiraLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0002-4817-8196
Evangelos StavropoulosLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, NW1 1AT, UK.
Jonathan M PittLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, NW1 1AT, UK.
Probir ChakravartyBioinformatics Core, The Francis Crick Institute, London, NW1 1AT, UK.
Annika WarnatschAntimicrobial Defence Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0003-2013-1625
William J BranchettInflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK.ORCID http://orcid.org/0000-0003-4353-4857
Laura ConejeroLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0001-6515-9221
Jing-Wen LinMalaria Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Sophia DavidsonImmunoregulation Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Mark S WilsonHelminth Immunology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0003-1737-1281
Gregory BancroftLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Jean LanghorneMalaria Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Eva FrickelHost-Toxoplasma Interaction Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0002-9515-3442
Abdul K SesayAdvanced Sequencing Facility, The Francis Crick Institute, London, NW1 1AT, UK.
Simon L PriestnallDepartment of Pathobiology & Population Sciences, Royal Veterinary College, London, AL9 7TA, UK.
Eleanor HerbertDepartment of Pathobiology & Population Sciences, Royal Veterinary College, London, AL9 7TA, UK.
Marianna IoannouAntimicrobial Defence Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0003-1304-2667
Qian WangAntimicrobial Defence Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Ian R HumphreysDivision of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University, Cardiff, CF14 4XN, UK.
Jonathan DoddRespiratory Infection Section, National Heart and Lung Institute, Imperial College London, London, W2 1PG, UK.
Peter J M OpenshawRespiratory Infection Section, National Heart and Lung Institute, Imperial College London, London, W2 1PG, UK.ORCID http://orcid.org/0000-0002-7220-2555
Katrin D Mayer-BarberInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Dragana JankovicImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Alan SherImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Clare M LloydInflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK.ORCID http://orcid.org/0000-0001-8977-6726
Nicole BaldwinBaylor Institute for Immunology Research, Dallas, TX, 75204, USA.
Damien ChaussabelSystems Biology and Immunology Department, Sidra Medicine, PO BOX 26999, Doha, Qatar.
Venizelos PapayannopoulosAntimicrobial Defence Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Andreas WackImmunoregulation Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0001-5226-2991
Jacques F BanchereauThe Jackson Laboratory for Genomic Medicine, Farmington, CT, 06030, USA.ORCID http://orcid.org/0000-0003-3535-7221
Virginia M PascualDrukier Institute for Children's Health, Weill Cornell Medical College, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-8806-8426
Anne O'GarraLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, NW1 1AT, UK. Anne.OGarra@crick.ac.uk.ORCID http://orcid.org/0000-0001-9845-6134
The Francis Crick Institute · GBNational Institutes of Health · USImperial College London · GBLung Institute · USRoyal Veterinary College · GBUniversity of London · GBBaylor University · USCardiff University · GBCornell University · USJackson Laboratory · USQatar Airways (Qatar) · QA
Funding
Innate inflammatory responses during pulmonary infectionsZIAAI001207 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MAYER-BARBER, KATRIN · 2015 to 2025
$13.6MImmune Regulation In Toxoplasmosis And Other Opportunistic InfectionsZIAAI000579 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SHER, ALAN · 2009 to 2022
$7.8MCancer Research UKMedical Research Council MC_U117565642Medical Research Council MC_U117597139Medical Research Council MC_UP_1202/12Wellcome Trust
Abstract
Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune signatures are dominated by either IFN-γ and IFN-inducible, IL-17-induced neutrophil- or allergy-associated gene expression. Type I IFN and IFN-γ-inducible, but not IL-17- or allergy-associated signatures, are preserved in the blood. While IL-17-associated genes identified in lung are detected in blood, the allergy signature is only detectable in blood CD4
Indexed as
AnimalsBurkholderia pseudomalleiCandida albicansCandidiasisGene Expression RegulationInfluenza A Virus, H3N2 SubtypeInterferon-gammaInterferon gamma ReceptorInterferon Type ILungMelioidosisMiceMice, Inbred C57BLOrthomyxoviridae InfectionsReceptor, Interferon alpha-betaReceptors, InterferonIfnar1 protein, mouseInterferon-gammaInterferon gamma ReceptorInterferon Type IReceptor, Interferon alpha-betaReceptors, Interferon
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