ArticleBMJ open2019
Cohort profile: Finnish Health and Early Life Microbiota (HELMi) longitudinal birth cohort.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Finnish Health and Early Life Microbiota (HELMi) Longitudinal Birth Cohort
Section-Born Infants and SUccessful Health Outcomes After Fecal Microbiota Transplantation (SISU-FMT)
Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- PREVENT 1, a nationwide Swedish infant cohort for longitudinal gut microbiome profiling and early-life health outcomes: cohort profile.BMJ open · 2026Observational
- Green Stool Predominance in Babies and Subsequent Bowel Function at 1-2 Years of Age.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Towards a Standard Protocol for Fecal Microbiota Transplantation in Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2026Review
- Impact of phage enrichment on the observed infant gut phageome.Microbiology spectrum · 2026Article
- The association of maternal and infant early gut microbiota with respiratory infections in infants.Pediatric research · 2026Article
- Associations between the infant gut microbiota and the living environment.Gut microbes reports · 2026Article
- Labor Induction with Synthetic Oxytocin and Infantile Colic: A Case-Control Study.Medicina (Kaunas, Lithuania) · 2025Article
- The Aggregated Gut Viral Catalogue (AVrC): A unified resource for exploring the viral diversity of the human gut.PLoS computational biology · 2025Article
- Examining the healthy human microbiome concept.Nature reviews. Microbiology · 2025Review
- Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- The influence of human milk composition and its microbiome on the gut microecology and early growth and development of preterm infants (the YI study): protocol design and cohort profile.Frontiers in nutrition · 2025Article
- Host-microbiota interactions in the infant gut revealed by daily faecal sample time series.Microbiome research reports · 2025Article
- Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants.Nature communications · 2024Observational
- Gut microbial factors predict disease severity in a mouse model of multiple sclerosis.Nature microbiology · 2024Article
- Early-life gut bacterial community structure predicts disease risk and athletic performance in horses bred for racing.Scientific reports · 2024Article
- Early-life gut microbiota associates with allergic rhinitis during 13-year follow-up in a Finnish probiotic intervention cohort.Microbiology spectrum · 2024Article
- Article
- In Utero Exposure to Antibiotics and Risk of Serious Infections in the First Year of Life.Drug safety · 2024Article
- Sources of gut microbiota variation in a large longitudinal Finnish infant cohort.EBioMedicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHELMi (Health and Early Life Microbiota) is a longitudinal, prospective general population birth cohort, set up to identify environmental, lifestyle and genetic factors that modify the intestinal microbiota development in the first years of life and their relation to child health and well-being.
participantsThe HELMi cohort consists of 1055 healthy term infants born in 2016-2018 mainly at the capital region of Finland and their parents. The intestinal microbiota development of the infants is characterised based on nine, strategically selected, faecal samples and connected to extensive online questionnaire-collected metadata at weekly to monthly intervals focusing on the diet, other exposures and family's lifestyle as well as the health and growth of the child. Motor and cognitive developmental screening takes place at 18 months. Infant's DNA sample, mother's breast milk sample and both parent's spot faecal samples have been collected. FINDINGS TO DATE: The mean age of the mothers was 32.8 (SD 4.1) and fathers/coparents 34.8 (5.3) years at the time of enrolment. Seventeen percentage (n=180) of the infants were born by caesarean section. Just under half (49%) were firstborns; 50.7% were males. At 3 months of age, 86% of the babies were exclusively breastfed and 2% exclusively formula-fed. FUTURE PLANS: The current follow-up from pregnancy to first 24 months will be completed in March 2020, totalling to over 10 000 biological samples and over 50 000 questionnaire entries. The results are expected to identify environmental and host factors that affect early gut microbiota development and health, and hence give indications of how to prevent or reverse microbiota perturbations in infancy. This prospective cohort will be followed up further to identify how the early microbiota relates to later health outcomes, especially weight gain, infections and allergic and other chronic diseases. TRIAL REGISTRATION NUMBER: NCT03996304; Pre-results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.