ArticleNeuron2019
Strengthened Temporal Coordination within Pre-existing Sequential Cell Assemblies Supports Trajectory Replay.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Offline generative network reconfiguration guides insight-like accelerated learning by assimilation into schema in rats.Nature communications · 2026Article
- Drift-diffusion dynamics of hippocampal replay.PLoS computational biology · 2026Article
- Experience reorganizes content-specific memory traces in macaques.Nature neuroscience · 2026Article
- Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience.Nature neuroscience · 2026Article
- Engrams and Memory: My Scientific "Eras Tour".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spaces and sequences in the hippocampus: a homological perspective.Journal of computational neuroscience · 2026Article
- Local Neuronal Ensembles That Coreactivate across Regions during Sleep Are Preferentially Stabilized.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Convergent information flows explain recurring firing patterns in cerebral cortex.Nature neuroscience · 2026Article
- Article
- Generative emergence of non-local representations in the hippocampus.Nature communications · 2025Article
- Formation and retrieval of cell assemblies in a biologically realistic spiking neural network model of area CA3 in the mouse hippocampus.Journal of computational neuroscience · 2024Article
- Article
- Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation.Nature communications · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
- Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies.Nature communications · 2024Article
- Nested compressed co-representations of multiple sequential experiences during sleep.Nature neuroscience · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.bioRxiv : the preprint server for biology · 2024Article
- Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A central goal in learning and memory research is to reveal the neural substrates underlying episodic memory formation. The hallmark of sequential spatial trajectory learning, a model of episodic memory, has remained equivocal, with proposals ranging from de novo creation of compressed sequential replay from blank slate networks to selection of pre-existing compressed preplay sequences. Here, we show that increased millisecond-timescale activation of cell assemblies expressed during de novo sequential experience and increased neuronal firing rate correlations can explain the difference between post-experience trajectory replay and robust preplay. This increased activation results from an improved neuronal tuning to specific cell assemblies, higher recruitment of experience-tuned neurons into pre-existing cell assemblies, and increased recruitment of cell assemblies in replay. In contrast, changes in overall neuronal and cell assembly temporal order within extended sequences do not account for sequential trajectory learning. We propose the coordinated strengthening of cell assemblies played sequentially on robust pre-existing temporal frameworks could support rapid formation of episodic-like memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.