ArticleJournal of neuroengineering and rehabilitation2019
Reduction of the onset response in kilohertz frequency alternating current nerve block with amplitude ramps from non-zero amplitudes.
Article in Journal of neuroengineering and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Ramped kilohertz-frequency signals produce nerve conduction block without onset response.Journal of neural engineering · 2025Article
- Fascicle-selective kilohertz-frequency neural conduction block with longitudinal intrafascicular electrodes.Journal of neural engineering · 2025Article
- Pudendal Nerve Block by Adaptively Stepwise Increasing the Intensity of High-Frequency (10 kHz) Biphasic Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Closed-Loop Multimodal Neuromodulation of Vagus Nerve for Control of Heart Rate.Proceedings of the ... American Control Conference. American Control Conference · 2024Article
- Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives.Frontiers in neuroscience · 2024Review
- High frequency alternating current neurostimulation decreases nocifensive behavior in a disc herniation model of lumbar radiculopathy.Bioelectronic medicine · 2023Article
- Combining direct current and kilohertz frequency alternating current to mitigate onset activity during electrical nerve block.Journal of neural engineering · 2021Article
- Kilohertz waveforms optimized to produce closed-state Na+ channel inactivation eliminate onset response in nerve conduction block.PLoS computational biology · 2020Article
- Temporal interference stimulation targets deep brain regions by modulating neural oscillations.Brain stimulationArticle
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundKilohertz frequency alternating current (KHFAC) waveforms reversibly block conduction in mammalian peripheral nerves. The initiation of the KHFAC produces nerve activation, called the onset response, before complete block occurs. An amplitude ramp, starting from zero amplitude, is ineffective in eliminating this onset activity. We postulated that initiating the ramp from a non-zero amplitude would produce a different effect on the onset.
methodsExperiments were conducted in an in vivo rat model. KHFAC was applied at supra block threshold amplitudes and then reduced to a lower sub block amplitude (25, 50, 75 and 90% of the block threshold amplitude). The amplitude was then increased again to the original supra block threshold amplitude with an amplitude ramp. This ramp time was varied for each of the amplitude levels tested.
resultsThe amplitude ramp was successful in eliminating a second onset. This was always possible for the ramps up from 75 and 90% block threshold amplitude, usually from 50% but never from 25% of the block threshold amplitude.
conclusionsThis maneuver can potentially be used to initiate complete nerve block, transition to partial block and then resume complete block without producing further onset responses.
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