ArticleBMC cancer2019
Outcome of segmental prosthesis reconstruction for diaphyseal bone tumors: a multi-center retrospective study.
Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Union, complication, reintervention and failure rates of surgical techniques for large diaphyseal defects: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Surgical management of tibial metastases: a systematic review.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Ultra Short Osteotomy With Mortise-Tenon Diaphyseal Prosthesis Reconstruction for Forearm Metastases: A Retrospective Study.Orthopaedic surgery · 2026Article
- Intercalary tumor prosthesis for recalcitrant humeral shaft nonunions: a case series and technique.JSES reviews, reports, and techniques · 2026Article
- Patient-specific Ti-6Al-4V lattice implants for critical-sized, weightbearing limb reconstruction: average 45-month surgical, oncological, and functional follow-up.Bone & joint open · 2026Article
- Intercalary Diaphyseal Endoprosthetic Reconstruction.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Review
- Ultra-short stem intercalary prosthetic reconstruction for joint preservation in metaphyseal tumor management: a retrospective review of twenty-five cases.BMC musculoskeletal disorders · 2025Article
- Biomechanically optimized 3D-Printed titanium prostheses with stiffener arrangement for critical femoral diaphyseal defects: early weight-bearing capacity and combat readiness validated through integrated biomechanical-FEA approach.Frontiers in bioengineering and biotechnology · 2025Article
- Clinical efficacy on the reconstruction of bone defects using modular hemipelvic prosthesis in patients with pelvic tumors.Journal of orthopaedic surgery and research · 2024Article
- Intramedullary Nail vs. Plate Fixation for Pathological Humeral Shaft Fracture: An Updated Narrative Review and Meta-Analysis of Surgery-Related Factors.Journal of clinical medicine · 2024Review
- Bifunctional bone substitute materials for bone defect treatment after bone tumor resection.Materials today. Bio · 2023Review
- A quantitative CT analysis of fibula inlayed in a massive allograft for femoral diaphysis reconstruction.Journal of bone oncology · 2023Article
- Reconstruction of massive bone defects after femoral tumor resection using two new-designed 3D-printed intercalary prostheses: a clinical analytic study with the cooperative utilization of multiple technologies.BMC musculoskeletal disorders · 2023Article
- Clinical efficacy of customized modular prosthesis in the treatment of femoral shaft metastases.Frontiers in oncology · 2023Article
- Hip-Preserved Reconstruction Using a Customized Cementless Intercalary Endoprosthesis With an Intra-Neck Curved Stem in Patients With an Ultrashort Proximal Femur: Midterm Follow-Up Outcomes.Frontiers in bioengineering and biotechnology · 2022Article
- Three-dimensional-printed porous prosthesis for the joint-sparing reconstruction of the proximal humeral tumorous defect.Frontiers in bioengineering and biotechnology · 2022Article
- Hip-preserving reconstruction using a customized cemented femoral endoprosthesis with a curved stem in patients with short proximal femur segments: Mid-term follow-up outcomes.Frontiers in surgery · 2022Article
- A comparison of cemented and cementless intra-neck curved stem use during hip-preserving reconstruction following massive femoral malignant tumor removal.Frontiers in oncology · 2022Article
- Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature.European journal of medical research · 2021Review
- Lower Limb Reconstruction Using Tibial Strut Autograft after Resection of Primary Malignant Bone Tumors in Skeletally Immature Patients.The archives of bone and joint surgery · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal reconstructive method after diaphyseal malignant bone tumor resection remains controversial. This multicenter clinical study was designed to investigate the clinical value and complications of segmental prosthesis in the repair of diaphyseal defects.
methodsWe present 49 patients from three clinical centers treated with wide resection for primary or metastatic bone tumors involving the diaphysis of the femur, tibia, humerus, or ulna, followed by reconstruction using a modular intramedullary segmental prosthesis.
resultsEnrolled patients included 23 men and 26 women with a mean age of 63.3 years. Of these, seven patients had primary bone tumors and 42 patients had metastatic lesions. At the mean follow-up of 13.7 months, 17 patients were alive, 31 patients were deceased due to tumor progression, and one patient was dead of another reason. There were eight nononcologic complications (two with radial nerve injury, three with delayed incision healing, two with aseptic loosening in the proximal humerus prosthetic stem and one with structural failure) and three oncologic complications (three with primary tumor recurrence) among all patients. The incidence of complications in primary tumor patients (4/7, 57.1%) was higher than that in patients with metastatic tumors (7/42, 16.7%) (p = 0.036). Aseptic loosening and mechanical complications were not common for patients with primary tumors, although the reconstruction length difference was statistically significant (p = 0.023). No statistically significant differences were observed in limb function, while the mean musculoskeletal tumor society score was 21.2 in femora, 19.6 in humeri, and 17.8 in tibiae (p = 0.134).
conclusionsSegmental prostheses represent an optional method for the reconstruction of diaphyseal defects in patients with limited life expectancy. Segmental prostheses in the humerus experienced more complications than those used to treat lesions in the femur.
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