ArticleOptics express2019
Measuring mechanical wave speed, dispersion, and viscoelastic modulus of the cornea using optical coherence elastography.
Article in Optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Biomechanical assessments of high-fluence corneal cross-linking with supplemental oxygen using optical coherence elastography inJournal of biomedical optics · 2026Article
- Super-resolution wave-dispersion analysis in optical coherence elastography using multiple signal classification (MUSIC).Biomedical optics express · 2026Article
- Air-Coupled Ultrasonic Optical Coherence Elastography Reveals Protocol-Dependent Corneal Stiffening in Epi-On and Epi-Off Riboflavin Crosslinking.Translational vision science & technology · 2026Article
- A Low-Cost Laser Interferometric Elastography System for Skin Elasticity Measurement.Bioengineering (Basel, Switzerland) · 2026Article
- Extracellular Matrix Viscoelasticity: A Dynamic Regulator of Cellular Behavior.Annals of biomedical engineering · 2025Review
- Optical Coherence Elastography Measures Mechanical Tension in the Lens and Capsule.Acta biomaterialia · 2025Article
- Ultrafast line-field holographic elastography with single excitation for corneal biomechanical characterization.Biomedical optics express · 2025Article
- A-scan sequence transformers for palpation with optical coherence elastography.Biomedical optics express · 2025Article
- Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography.Translational vision science & technology · 2025Article
- In Vivo Optical Coherence Elastography Unveils Spatial Variation of Human Corneal Stiffness.IEEE transactions on bio-medical engineering · 2024Article
- Simultaneous tensile and shear measurement of the human cornea in vivo using S0- and A0-wave optical coherence elastography.Acta biomaterialia · 2024Article
- High-Frequency Optical Coherence Elastography for Gingival Tissue Characterization: Variability in Stiffness and Response to Physiological Conditions.Biomaterials research · 2024Article
- Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastography.APL bioengineering · 2023Article
- Ultra-wideband optical coherence elastography from acoustic to ultrasonic frequencies.Nature communications · 2023Article
- Article
- Linear viscoelasticity of human sclera and posterior ocular tissues during tensile creep.Journal of biomechanics · 2023Article
- Noncontact Acoustic Micro-Tapping Optical Coherence Elastography for Quantification of Corneal Anisotropic Elasticity: In Vivo Rabbit Study.Translational vision science & technology · 2023Article
- Article
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Supershear surface waves reveal prestress and anisotropy of soft materials.Journal of the mechanics and physics of solids · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Acoustic wave velocity measurement based on optical coherence tomography (OCT) is a promising approach to assess the mechanical properties of biological tissues and soft materials. While studies to date have demonstrated proof of concept of different ways to excite and detect mechanical waves, the quantitative performance of this modality as mechanical measurement has been underdeveloped. Here, we investigate the frequency dependent measurement of the wave propagation in viscoelastic tissues, using a piezoelectric point-contact probe driven with various waveforms. We found that a frequency range of 2-10 kHz is a good window for corneal elastography, in which the lowest-order flexural waves can be identified in post processing. We tested our system on tissue-simulating phantoms and ex vivo porcine eyes, and demonstrate reproducibility and inter-sample variability. Using the Kelvin-Voigt model of viscoelasticity, we extracted the shear-elastic modulus and viscosity of the cornea and their correlation with the corneal thickness, curvature, and eyeball mass. Our results show that our method can be a quantitative, useful tool for the mechanical analysis of the cornea.
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