ArticleInternational journal of molecular sciences2019
Intestinal Preservation Injury: A Comparison Between Rat, Porcine and Human Intestines.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Deep eutectic solvents@enteric technology for orally delivering anticoagulant macromolecule drug.Acta pharmaceutica Sinica. B · 2026Article
- A localized vertebral infection model of pyogenic spondylitis induced byFrontiers in medicine · 2025Article
- Normothermic Preservation of the Intestinal Allograft.Gastroenterology clinics of North America · 2024Review
- Red blood cell-derived materials for cancer therapy: Construction, distribution, and applications.Materials today. Bio · 2024Review
- Endogenous chitinase might lead to differences in growth performance and intestinal health of piglets fed different levels of black soldier fly larva meal.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Modulation of the intestinal bacterial flora: a viable strategy to alleviate acute mesenteric ischemia?Annals of translational medicine · 2023Article
- Hypothermic machine perfusion alleviates ischemia-reperfusion injury of intestinal transplantation in pigs.Frontiers in immunology · 2023Article
- Experimental Assessment of Intestinal Damage in Controlled Donation After Circulatory Death for Visceral Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Preclinical Study of DCD and Normothermic Perfusion for Visceral Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Characterizing Autophagy in the Cold Ischemic Injury of Small Bowel Grafts: Evidence from Rat Jejunum.Metabolites · 2021Article
- DietaryFrontiers in veterinary science · 2021Article
- Special Issue on "The Tight Junction and Its Proteins: More than Just a Barrier".International journal of molecular sciences · 2020Article
- Characterization of the intestinal graft in a swine hypotensive after brain death model.Acta cirurgica brasileira · 2020Article
- Intestinal preservation using a tailored luminal solution and aeration: A small animal study.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advanced preservation injury (PI) after intestinal transplantation has deleterious short- and long-term effects and constitutes a major research topic. Logistics and costs favor rodent studies, whereas clinical translation mandates studies in larger animals or using human material. Despite diverging reports, no direct comparison between the development of intestinal PI in rats, pigs, and humans is available. We compared the development of PI in rat, porcine, and human intestines. Intestinal procurement and cold storage (CS) using histidine-tryptophan-ketoglutarate solution was performed in rats, pigs, and humans. Tissue samples were obtained after 8, 14, and 24 h of CS), and PI was assessed morphologically and at the molecular level (cleaved caspase-3, zonula occludens, claudin-3 and 4, tricellulin, occludin, cytokeratin-8) using immunohistochemistry and Western blot. Intestinal PI developed slower in pigs compared to rats and humans. Tissue injury and apoptosis were significantly higher in rats. Tight junction proteins showed quantitative and qualitative changes differing between species. Significant interspecies differences exist between rats, pigs, and humans regarding intestinal PI progression at tissue and molecular levels. These differences should be taken into account both with regards to study design and the interpretation of findings when relating them to the clinical setting.
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Registered trials
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