Evidence map›Paper›PMID 31252256›Full record

ArticleBiosensors & bioelectronics2019

Detecting acid phosphatase enzymatic activity with phenol as a chemical exchange saturation transfer magnetic resonance imaging contrast agent (PhenolCEST MRI).

Jia Zhang, Yue Yuan, Zheng Han, Yuguo Li, Peter C M van Zijl, Xing Yang, Jeff W M Bulte, Guanshu Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. A dual-signal fluorescent probe for detection of acid phosphatase.Analytical and bioanalytical chemistry · 2021
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jia ZhangThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Yue YuanThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Zheng HanThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Yuguo LiThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Peter C M van ZijlThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States.
Xing YangDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, China.
Jeff W M BulteThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States.
Guanshu LiuThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States. Electronic address: guanshu@mri.jhu.edu.
Johns Hopkins University · USKennedy Krieger Institute · USPeking University First Hospital · CN

Funding

Novel Approaches for CEST Labeling, Detection, Quantification and TranslationR01EB015032 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2011 to 2019
$3.9M
Noninvasive prediction of tumor response to gemcitabine using MRIR01CA211087 · NCI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LIU, GUANSHU · 2017 to 2020
$1.5M
CEST MRI assessment of tumor vascular permeability using non-labeled dextransR21CA215860 · NCI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LIU, GUANSHU · 2017 to 2018
$352k
Optimization of CEST MRI for detection of bacteriaR03EB021573 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LIU, GUANSHU · 2016 to 2017
$162k
NCI NIH HHS R01 CA211087NCI NIH HHS R21 CA215860NIBIB NIH HHS R01 EB015032NIBIB NIH HHS R03 EB021573
6 · The paper itself

Abstract

Phenol contains an exchangeable hydroxyl proton resonant at 4.8 ppm from the resonance frequency of water in the

Indexed as

Acid PhosphataseBiosensing TechniquesCell LineContrast MediaHumansMagnetic Resonance ImagingMalePhenolProstateAcid PhosphataseContrast MediaPhenolAcid phosphataseBiosensorCEST MRIEnzymePhenolProstate cells

Identifiers

PMID31252256
PMCPMC6717000
OpenAlexW2950400487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.