Evidence map›Paper›PMID 31251848›Full record

SynthesisInternational forum of allergy & rhinology2019

Hyams grading as a predictor of metastasis and overall survival in esthesioneuroblastoma: a meta-analysis.

Khodayar Goshtasbi, Arash Abiri, Mehdi Abouzari, Ronald Sahyouni, Beverly Y Wang, Bobby A Tajudeen, Frank P K Hsu, Gilbert Cadena, Edward C Kuan

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International forum of allergy & rhinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Surgical Management of Esthesioneuroblastoma at a Single Tertiary Care Center.Journal of neurological surgery. Part B, Skull base · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Khodayar GoshtasbiDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA.
Arash AbiriDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA.
Mehdi AbouzariDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA.
Ronald SahyouniDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA.
Beverly Y WangDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA.
Bobby A TajudeenDepartment of Otolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL.
Frank P K HsuDepartment of Neurological Surgery, University of California, Irvine, CA.
Gilbert CadenaDepartment of Neurological Surgery, University of California, Irvine, CA.
Edward C KuanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA.ORCID 0000-0003-3475-0718

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
NCATS NIH HHS TL1 TR001415NIGMS NIH HHS T32 GM008620
6 · The paper itself

Abstract

backgroundEsthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, represents up to 3% of all sinonasal neoplasms. Hyams histologic grading is a promising tool in predicting metastases and establishing prognoses for this complex tumor.

methodsA systematic literature search was performed in the PubMed, Ovid MEDLINE, and Cochrane databases. ENB patients with Hyams I-II or III-IV were categorized as low-grade Hyams (LGH) or high-grade Hyams (HGH), respectively. Binary and continuous random-effects models were applied to calculate odds ratios (ORs) for the incidences of neck and distal metastases as well as for 5- and 10-year overall survival rates.

resultsOf the 57 screened articles published from 1993 to 2018, 16 (525 patients) and 21 (563 patients) provided data for tumor metastases and overall survival rates, respectively. Neck metastasis was observed in 18.2% of HGH vs 7.9% of LGH patients. Distant metastasis was noted in 20.7% of HGH vs 8.9% of LGH patients. LGH patients had 5- and 10-year overall survival rates of 81.2% and 64.0%, respectively, as compared with 60.9% and 40.6%, respectively, for HGH patients. In comparing HGHs vs LGHs, the collective ORs for neck and distant metastases were 2.08 (95% confidence interval [CI], 1.09-3.99; p = 0.03) and 2.37 (95% CI, 1.07-5.26; p = 0.03), respectively. Moreover, in comparing LGHs vs HGHs, collective ORs for 5- and 10-year overall survival rates were 3.39 (95% CI, 2.09-5.49; p < 0.001) and 3.03 (95% CI, 1.82-5.06; p < 0.001), respectively.

conclusionHGH ENBs, compared with LGH ENBs, are more likely to metastasize to neck or distal targets and to have lower overall survival rates.

Indexed as

Esthesioneuroblastoma, OlfactoryHumansIncidenceModels, StatisticalNasal CavityNeoplasm MetastasisNeoplasm StagingNose NeoplasmsPrognosisSurvival Analysisesthesioneuroblastomameta-analysismetastasisolfactory neuroblastomasurvival

Identifiers

PMID31251848
PMCPMC7276257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.