Evidence map›Paper›PMID 31251478›Full record

ArticleInfluenza and other respiratory viruses2019

Circulation and characterization of seasonal influenza viruses in Cambodia, 2012-2015.

Paul F Horwood, Erik A Karlsson, Srey Viseth Horm, Sovann Ly, Seng Heng, Savuth Chin, Chau Darapheak, David Saunders, Lon Chanthap, Sareth Rith and 12 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  9. An influenza A (H3N2) virus outbreak in the Kingdom of Cambodia during the COVID-19 pandemic of 2020.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Paul F HorwoodVirology Unit, Institute Pasteur in Cambodia, Institute Pasteur International Network, Phnom Penh, Cambodia.ORCID 0000-0001-9622-0742
Erik A KarlssonVirology Unit, Institute Pasteur in Cambodia, Institute Pasteur International Network, Phnom Penh, Cambodia.ORCID 0000-0001-6004-5671
Srey Viseth HormVirology Unit, Institute Pasteur in Cambodia, Institute Pasteur International Network, Phnom Penh, Cambodia.
Sovann LyCommunicable Disease Control Department, Ministry of Health, Phnom Penh, Cambodia.
Seng HengCommunicable Disease Control Department, Ministry of Health, Phnom Penh, Cambodia.
Savuth ChinNational Institute of Public Health, Phnom Penh, Cambodia.
Chau DarapheakNational Institute of Public Health, Phnom Penh, Cambodia.
David SaundersArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Lon ChanthapArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Sareth RithVirology Unit, Institute Pasteur in Cambodia, Institute Pasteur International Network, Phnom Penh, Cambodia.
Phalla YVirology Unit, Institute Pasteur in Cambodia, Institute Pasteur International Network, Phnom Penh, Cambodia.
Kim Lay CheaVirology Unit, Institute Pasteur in Cambodia, Institute Pasteur International Network, Phnom Penh, Cambodia.
Borann SarCenters for Disease Control and Prevention, Phnom Penh, Cambodia.
Amy ParryWorld Health Organization, Phnom Penh, Cambodia.
Vanra IengWorld Health Organization, Phnom Penh, Cambodia.
Reiko TsuyoukaWorld Health Organization, Phnom Penh, Cambodia.
Yi-Mo DengWHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute, Melbourne, Victoria, Australia.
Aeron C HurtWHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute, Melbourne, Victoria, Australia.ORCID 0000-0003-1826-4314
Ian G BarrWHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute, Melbourne, Victoria, Australia.
Naomi KomadinaWHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute, Melbourne, Victoria, Australia.
Philippe BuchyVirology Unit, Institute Pasteur in Cambodia, Institute Pasteur International Network, Phnom Penh, Cambodia.
Philippe DussartVirology Unit, Institute Pasteur in Cambodia, Institute Pasteur International Network, Phnom Penh, Cambodia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfluenza virus circulation is monitored through the Cambodian influenza-like illness (ILI) sentinel surveillance system and isolates are characterized by the National Influenza Centre (NIC). Seasonal influenza circulation has previously been characterized by year-round activity and a peak during the rainy season (June-November).

objectivesWe documented the circulation of seasonal influenza in Cambodia for 2012-2015 and investigated genetic, antigenic, and antiviral resistance characteristics of influenza isolates. PATIENTS/

methodsRespiratory samples were collected from patients presenting with influenza-like illness (ILI) at 11 hospitals throughout Cambodia. First-line screening was conducted by the National Institute of Public Health and the Armed Forces Research Institute of Medical Sciences. Confirmation of testing and genetic, antigenic and antiviral resistance characterization was conducted by Institute Pasteur in Cambodia, the NIC. Additional virus characterization was conducted by the WHO Collaborating Centre for Reference and Research on Influenza (Melbourne, Australia).

resultsBetween 2012 and 2015, 1,238 influenza-positive samples were submitted to the NIC. Influenza A(H3N2) (55.3%) was the dominant subtype, followed by influenza B (30.9%; predominantly B/Yamagata-lineage) and A(H1N1)pdm09 (13.9%). Circulation of influenza viruses began earlier in 2014 and 2015 than previously described, coincident with the emergence of A(H3N2) clades 3C.2a and 3C.3a, respectively. There was high diversity in the antigenicity of A(H3N2) viruses, and to a smaller extent influenza B viruses, during this period, with some mismatches with the northern and southern hemisphere vaccine formulations. All isolates tested were susceptible to the influenza antiviral drugs oseltamivir and zanamivir.

conclusionsSeasonal and year-round co-circulation of multiple influenza types/subtypes were detected in Cambodia during 2012-2015.

Indexed as

Drug Resistance, ViralSeasonsSentinel SurveillanceAdolescentAdultAgedAntiviral AgentsCambodiaChildChild, PreschoolFemaleHumansInfantInfant, NewbornInfluenza A virusInfluenza B virusAntiviral AgentsInfluenza VaccinesA(H1N1)pdm09A(H3N2)Cambodiainfluenza A virusinfluenza B virussurveillance

Identifiers

PMID31251478
PMCPMC6692578

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.