Evidence map›Paper›PMID 31251471›Full record

ArticleJournal of cellular and molecular medicine2019

Bryostatin-1 ameliorated experimental colitis in Il-10

Lugen Zuo, Jing Li, Sitang Ge, Yuanyuan Ge, Mengdi Shen, Yan Wang, Changmin Zhou, Rong Wu, Jianguo Hu

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferationNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  10. Article
  11. Review
  12. Epac-2 ameliorates spontaneous colitis in Il-10Journal of cellular and molecular medicine · 2022
    Article
  13. Article
  14. Targeting ADAM10 in Cancer and Autoimmunity.Frontiers in immunology · 2020
    Review
  15. Bryostatin-1 ameliorated experimental colitis in Il-10Journal of cellular and molecular medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lugen ZuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, China.ORCID 0000-0003-0084-2681
Jing LiAnhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China.ORCID 0000-0002-1690-9548
Sitang GeDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Yuanyuan GeDepartment of Colorectal Surgery, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Mengdi ShenAnhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China.
Yan WangAnhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China.
Changmin ZhouAnhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China.
Rong WuDepartment of General Surgery, Zhongda Hospital, Southeast University, Nanjing, China.
Jianguo HuAnhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China.
Bengbu Medical College · CNNanjing University of Chinese Medicine · CNZhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bryostatin-1 (Bry-1) has been proven to be effective and safe in clinical trials of a variety of immune-related diseases. However, little is known about its effect on Crohn's disease (CD). We aimed to investigate the impact of Bry-1 on CD-like colitis and determine the mechanism underlying this effect. In the present study, 15-week-old male Il-10

Indexed as

AnimalsApoptosisBryostatinsColitisDown-RegulationEpithelial CellsInterleukin-10IntestinesMice, Inbred C57BLNF-E2-Related Factor 2PermeabilitySignal TransductionTh17 CellsTh1 CellsTight Junction ProteinsTight Junctionsbryostatin 1BryostatinsInterleukin-10Nfe2l2 protein, mouseNF-E2-Related Factor 2Tight Junction Proteinsbryostatin-1Crohn's diseaseintestinal barrierintestinal mucosal immunity

Identifiers

PMID31251471
PMCPMC6652299
OpenAlexW2955198107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.