ArticleMolecular biology and evolution2019
Ancient Hybridization and Adaptive Introgression of an Invadolysin Gene in Schistosome Parasites.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 103 citations in OpenAlex.
- Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemicScience advances · 2026Article
- Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture.Molecular ecology resources · 2025Article
- The research contribution of the Schistosomiasis Collection at the Natural History Museum (SCAN): highlights, challenges and future directions.Infectious diseases of poverty · 2025Review
- Genomic data reveal a north-south split and introgression history of blood fluke populations across Africa.Nature communications · 2025Article
- A pilot investigation of bovine schistosomiasis on Unguja Island, Zanzibar, raises a new concern for elimination of urogenital schistosomiasis.Parasites & vectors · 2025Article
- Response to "Schistosoma bovis Infecting Humans in Nigeria".The American journal of tropical medicine and hygiene · 2025Article
- Imported Schistosomiasis in Southwestern Europe: Wide Variation of Pure and Hybrid Genotypes Infecting Sub-Saharan Migrants.Transboundary and emerging diseases · 2025Article
- Schistosoma haematobium and Schistosoma bovis first generation hybrids undergo gene expressions changes consistent with species compatibility and heterosis.PLoS neglected tropical diseases · 2024Article
- Extant interspecific hybridization among trematodes within the Schistosoma haematobium species complex in Nigeria.PLoS neglected tropical diseases · 2024Article
- Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Interspecific introgression of MHC genes in Triturus newts: Evidence from multiple contact zones.Molecular ecology · 2023Article
- Bulinus snails in the Lake Victoria Basin in Kenya: Systematics and their role as hosts for schistosomes.PLoS neglected tropical diseases · 2023Article
- Cost-saving population genomic investigation ofEcology and evolution · 2022Article
- Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination.eLife · 2022Review
- Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities.PLoS neglected tropical diseases · 2022Article
- Genomic evidence of contemporary hybridization between Schistosoma species.PLoS pathogens · 2022Article
- Mating Interactions betweenMicroorganisms · 2022Article
- Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.Molecular ecology · 2022Article
- Population Genetic Structure and Hybridization ofPathogens (Basel, Switzerland) · 2022Article
- Comparative mitogenomics of freshwater snails of the genus Bulinus, obligatory vectors of Schistosoma haematobium, causative agent of human urogenital schistosomiasis.Scientific reports · 2022Article
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
Introgression among parasite species has the potential to transfer traits of biomedical importance across species boundaries. The parasitic blood fluke Schistosoma haematobium causes urogenital schistosomiasis in humans across sub-Saharan Africa. Hybridization with other schistosome species is assumed to occur commonly, because genetic crosses between S. haematobium and livestock schistosomes, including S. bovis, can be staged in the laboratory, and sequencing of mtDNA and rDNA amplified from microscopic miracidia larvae frequently reveals markers from different species. However, the frequency, direction, age, and genomic consequences of hybridization are unknown. We hatched miracidia from eggs and sequenced the exomes from 96 individual S. haematobium miracidia from infected patients from Niger and the Zanzibar archipelago. These data revealed no evidence for contemporary hybridization between S. bovis and S. haematobium in our samples. However, all Nigerien S. haematobium genomes sampled show hybrid ancestry, with 3.3-8.2% of their nuclear genomes derived from S. bovis, providing evidence of an ancient introgression event that occurred at least 108-613 generations ago. Some S. bovis-derived alleles have spread to high frequency or reached fixation and show strong signatures of directional selection; the strongest signal spans a single gene in the invadolysin gene family (Chr. 4). Our results suggest that S. bovis/S. haematobium hybridization occurs rarely but demonstrate profound consequences of ancient introgression from a livestock parasite into the genome of S. haematobium, the most prevalent schistosome species infecting humans.
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