ArticleThe Journal of clinical endocrinology and metabolism2019
Disrupted Oxytocin-Appetite Signaling in Females With Anorexia Nervosa.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Oxytocin levels do not change around a meal and correlate with reward-driven caloric consumption in adults with obesity.Diabetes, obesity & metabolism · 2026Article
- Decoding the Spectrum of Anorexia Nervosa: Clinical Impact, Molecular Insights, and Therapeutic Perspectives.Biomolecules · 2025Review
- Circadian copeptin and oxytocin profiles in anorexia nervosa: Exploring the interplay with neurohypophysis opioid tone.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- Exogenous oxytocin administered to induce or augment labour is positively associated with quality of observed mother-infant bonding.Comprehensive psychoneuroendocrinology · 2024Article
- The relationship between cannabis and anorexia nervosa: a scoping review.Journal of eating disorders · 2023Article
- Oxytocin response to food intake in avoidant/restrictive food intake disorder.European journal of endocrinology · 2023Article
- Serum Oxytocin Levels Decrease 12 Months Following Sleeve Gastrectomy and Are Associated with Decreases in Lean Mass.International journal of molecular sciences · 2023Article
- Differential comorbidity profiles in avoidant/restrictive food intake disorder and anorexia nervosa: Does age play a role?The International journal of eating disorders · 2022Article
- Low oxytocin levels are broadly associated with more pronounced psychopathology in anorexia nervosa with primarily restricting but not binge/purge eating behavior.Frontiers in endocrinology · 2022Article
- Increased plasma asprosin levels in patients with drug-naive anorexia nervosa.Eating and weight disorders : EWD · 2021Article
- Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020Review
- Developmental stage-dependent relationships between ghrelin levels and hippocampal white matter connections in low-weight anorexia nervosa and atypical anorexia nervosa.Psychoneuroendocrinology · 2020Article
- Metabolic Effects of Oxytocin.Endocrine reviews · 2020Review
- Eighteen-month Course and Outcome of Adolescent Restrictive Eating Disorders: Persistence, Crossover, and Recovery.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Observational
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
contextIn healthy females, oxytocin levels decrease postmeal, corresponding to increased satiety. The postprandial response of oxytocin in females with anorexia nervosa (AN)/atypical AN is unknown.
objectivesTo determine the pattern of postprandial serum oxytocin levels in females with AN/atypical AN, relationship with appetite, and effect of weight, eating behavior, and endogenous estrogen status.
designCross-sectional.
settingClinical research center.
participants67 women (36 with AN [<85% expected body weight (EBW)]; 31 with atypical AN [≥ 85% EBW)]), age 22.4 ± 0.9 (mean ± SEM) years, categorized by weight, restricting vs binge/purge behavior, and estrogen status.
interventionsStandardized mixed meal. MAIN OUTCOME MEASUREMENTS: Blood sampling for oxytocin occurred fasting and 30, 60, and 120 minutes postmeal. Subjective appetite was assessed using visual analog scales.
resultsIn females with AN/atypical AN, oxytocin levels decreased from fasting to 60 (P = 0.002) and 120 (P = 0.005) minutes postmeal. The decrease in oxytocin from fasting to 120 minutes was greater in females with atypical AN than AN (P = 0.027) and did not differ by restricting vs binge/purge behavior or estrogen status. Controlling for caloric intake, the decrease in oxytocin was inversely related to the decrease in hunger postmeal in females with atypical AN (P = 0.04).
conclusionsIn females with AN/atypical AN, oxytocin levels decrease postmeal, as established in healthy females. Weight, but not restricting vs binge/purging nor endogenous estrogen status, affects postprandial oxytocin levels. The postprandial change in serum oxytocin levels is related to appetite in females with atypical AN only, suggesting a disconnect between oxytocin secretion and appetite in the undernourished state.
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