Evidence map›Paper›PMID 31251104›Full record

ArticleBioanalysis2019

Standard-flow LC and thermal focusing ESI elucidates altered liver proteins in late stage Niemann-Pick, type C1 disease.

Melissa R Pergande, Estefania Zarate, Carol Haney-Ball, Cristin D Davidson, Giuseppe Scesa, Maria I Givogri, Ernesto R Bongarzone, Stephanie M Cologna

Open access · greenAbstract read
In one paragraph

Article in Bioanalysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice.International journal of molecular sciences · 2021
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Melissa R PergandeDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Estefania ZarateDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Carol Haney-BallAgilent Technologies, Cary, NC 27518, USA.
Cristin D DavidsonAlbert Einstein College of Medicine, Bronx, NY 10461, USA.
Giuseppe ScesaDepartment of Anatomy & Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Maria I GivogriDepartment of Anatomy & Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Ernesto R BongarzoneDepartment of Anatomy & Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Stephanie M ColognaDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
University of Illinois Chicago · USAgilent Technologies (United States) · USAlbert Einstein College of Medicine · US

Funding

Substrate Reduction Therapies for Niemann-Pick C DiseaseR01NS053677 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DOBRENIS, KOSTANTIN, WALKLEY, STEVEN UPSHAW · 2006 to 2016
$3.3M
Combined Neuroprotection and Metabolic Correction to Treat LeukodystrophiesR01NS065808 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BONGARZONE, ERNESTO ROQUE · 2009 to 2018
$3.0M
NINDS NIH HHS R01 NS053677NINDS NIH HHS R01 NS065808
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

TemperatureAnimalsChromatography, LiquidHumansIntracellular Signaling Peptides and ProteinsLiverLiver DiseasesMiceMice, KnockoutNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CProteomicsSpectrometry, Mass, Electrospray IonizationIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinNpc1 protein, mouseAJS-ESIbiomarkerion funnelmass spectrometryNiemann–Pick type C1NPCproteomicsthermal gradient focusing

Identifiers

PMID31251104
PMCPMC9933893
OpenAlexW2954907128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.