Evidence map›Paper›PMID 31251083›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis.

Jae Young Lee, Shebli Mehrazarin, Abdullah Alshaikh, Sol Kim, Wei Chen, Renate Lux, Yousang Gwack, Reuben H Kim, Mo K Kang

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Histone demethylases in autophagy and inflammation.Cell communication and signaling : CCS · 2025
    Review
  6. Review
  7. The Roles of H3K9me3 Writers, Readers, and Erasers in Cancer Immunotherapy.International journal of molecular sciences · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Article
  16. Review
  17. The Role of Epigenomics in Osteoporosis and Osteoporotic Vertebral Fracture.International journal of molecular sciences · 2020
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jae Young Lee *The Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California-Los Angeles (UCLA) School of Dentistry, Los Angeles, California, USA.
Shebli Mehrazarin *The Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California-Los Angeles (UCLA) School of Dentistry, Los Angeles, California, USA.
Abdullah AlshaikhThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California-Los Angeles (UCLA) School of Dentistry, Los Angeles, California, USA.
Sol KimThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California-Los Angeles (UCLA) School of Dentistry, Los Angeles, California, USA.
Wei ChenThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California-Los Angeles (UCLA) School of Dentistry, Los Angeles, California, USA.
Renate LuxSection of Periodontics, Division of Constitutive and Regenerative Sciences, University of California-Los Angeles (UCLA) School of Dentistry, Los Angeles, California, USA; and.
Yousang GwackDepartment of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Reuben H KimThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California-Los Angeles (UCLA) School of Dentistry, Los Angeles, California, USA.
Mo K KangThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California-Los Angeles (UCLA) School of Dentistry, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

Novel regulators of store-operated Ca2+ entry in immune systemsR01AI083432 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2009 to 2020
$3.8M
Role of histone demethylase Kdm3C in age-associated oral and systemic inflammationR21DE028269 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG, KANG, MO K. · 2018 to 2019
$429k
Epigenetic role of GRHL2 in HPV-associated oral cancerR56DE024593 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KANG, MO K. · 2014 to 2014
$284k
Epigenetic regulation of radiation damage in oral mucosaR03DE024259 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, WEI · 2015 to 2016
$231k
NIAID NIH HHS R01 AI083432NIDCR NIH HHS R03 DE024259NIDCR NIH HHS R21 DE028269NIDCR NIH HHS R56 DE024593
6 · The paper itself

Abstract

Histone Lys-specific demethylases (KDMs) play a key role in many biological processes through epigenetic mechanisms. However, the role of KDMs in inflammatory responses to oral bacterial infection is poorly understood. Here, we show a novel regulatory role of KDM3C in inflammatory responses to oral bacterial infection. KDM3C expression is transiently suppressed in human and mouse macrophages exposed to LPS from

Indexed as

OsteogenesisAnimalsBacteroidaceae InfectionsCell DifferentiationCytokinesHistonesHumansInflammationJumonji Domain-Containing Histone DemethylasesLipopolysaccharidesMacrophagesMiceMice, KnockoutMouth DiseasesNF-kappa BOsteoclastsCytokinesHistonesJumonji Domain-Containing Histone DemethylasesLipopolysaccharidesNF-kappa Bepigeneticshistone methylationJMJD1Coral inflammationperiodontitis

Identifiers

PMID31251083
PMCPMC6704463
OpenAlexW2956140411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.