Evidence map›Paper›PMID 31250488›Full record

ReviewPhytochemical analysis : PCA2019

A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds.

Lauren Ford, Katerina Theodoridou, Gary N Sheldrake, Pamela J Walsh

Open access · hybridAbstract readReview
In one paragraph

Review in Phytochemical analysis : PCA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 125 citations in OpenAlex.

  1. Review
  2. Antidiabetic Effects ofMarine drugs · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Sustainable Recovery of Phlorotannins fromAntioxidants (Basel, Switzerland) · 2025
    Article
  9. Foods (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Article
  12. Light-mediated temperature susceptibility of kelp species (Cambridge prisms. Coastal futures · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Antioxidants (Basel, Switzerland) · 2023
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lauren FordSchool of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, UK.ORCID https://orcid.org/0000-0003-2350-8678
Katerina TheodoridouInstitute of Global Food Security, Queen's University Belfast, Belfast, UK.
Gary N SheldrakeSchool of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, UK.
Pamela J WalshSchool of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, UK.
Queen's University Belfast · GB

Funding

Invest NI R3936CCE
6 · The paper itself

Abstract

introductionPhlorotannins, the phenolic compounds found in brown seaweeds, are a unique and diverse class of compounds showing a huge potential for food and pharmaceutical applications.

objectiveThis review will give an account of the colorimetric assays used and a discussion of their quantitative and qualitative analytical shortcomings. It will also discuss other more complex and modern analytical chemistry methods that are currently being developed to study phlorotannins. The purpose of this review is to increase awareness of these bioactive compounds and promote further development of robust analytical methods for use in biology, food science, pharmacology and biomedical and cosmeceutical sciences.

resultsWhilst the biological activity and huge commercial potential of the phlorotannins has been widely reported throughout the literature, the chemical structures and reactivity of these compounds is still not well understood. The phlorotannin content of seaweed is usually characterised using colorimetric assays. However, although these methods give a reasonable overall estimation of the total phenolic content, they lack precision and specificity.

conclusionThis review highlights the strengths and weaknesses of commonly used colorimetric assays. Novel techniques are highlighted using more selective chemistry to identify this class of compounds.

Indexed as

Carbon-13 Magnetic Resonance SpectroscopyChromatography, High Pressure LiquidMass SpectrometryMolecular StructurePhenolsSeaweedTanninsPhenolsTanninsalgaeanalysisphlorotanninspolyphenolsseaweed

Identifiers

PMID31250488
PMCPMC6852508
OpenAlexW2944958544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.