Evidence map›Paper›PMID 31250447›Full record

Observational studyInternational journal of dermatology2019

Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch-Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression.

Qiang Liu, Yun Yang, Shealinna Ge, JianLi Huo, DaHu Wang, YaoHui Ma, ShaoMin Shi, Ding Luo, JieHua Deng, CuiMin Ren and 1 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Neuroprotective Effect of WhiteFoods (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Qiang LiuDermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.ORCID https://orcid.org/0000-0001-7135-3100
Yun YangDermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.
Shealinna GeDermatovenerological Department, University of Maryland School of Medicine,, Baltimore, MD, USA.
JianLi HuoDermatovenerological Department, Central Hospital, Zhuozhou, HeBei Province, China.
DaHu WangDermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.
YaoHui MaDermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.
ShaoMin ShiDermatovenerological Department, Shijiazhuang Fifth Hospital, Shijiazhuang, HeBei Province, China.
Ding LuoDermatovenerological Department, Affiliated Hospital of Hebei University, Baoding, HeBei Province, China.
JieHua DengDermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.
CuiMin RenDermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.
BingShen GuoDermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.
Hebei Medical University · CNAffiliated Hospital of Hebei University · CNFifth Hospital of Shijiazhuang · CNShuozhou Central Hospital · CNUniversity of Maryland, Baltimore · US

Funding

Hebei Province Natural Science Foundation H2016206383
6 · The paper itself

Abstract

backgroundHenoch-Schonlein purpura (HSP) is a systemic small vessel vasculitis that is mainly caused by IgA1-type immune complex deposition. Advanced oxidation protein products (AOPPs) are specific markers of protein oxidation.

objectiveTo explore the role of AOPPs in the pathogenesis of HSP.

methodsThere are 51 HSP patients who were divided into four subgroups: (i) skin type - 20 cases; (ii) joint type - 8 cases; (iii) abdominal type - 12 cases; (iv) renal type - 11 cases; and 18 healthy volunteers were enrolled as controls. The serum levels of AOPPs and Gd-IgA1 were quantified by an HAA-lectin-based ELISA. The Cosmc mRNA expression in peripheral B lymphocytes was measured by RT-PCR.

results1. Advanced oxidation protein products in different subgroups of HSP patients are all higher than the controls, while the renal-type subgroup is the highest and the skin-type subgroup is the lowest. 2. Spearman correlation analysis shows that: (i) AOPPs and Gd-IgA1 in HSP patients are positively correlated; both of them are positively correlated with the disease severity scores; (ii) AOPPs are negatively correlated with the relative expression value (RQ) of Cosmc mRNA.

conclusionAdvanced oxidation protein products play an important role in the pathogenesis of HSP, especially in renal-type patients.

Indexed as

AdolescentAdultAdvanced Oxidation Protein ProductsBiomarkersB-LymphocytesChildFemaleGlycosylationHumansIgA VasculitisImmunoglobulin AMaleMolecular ChaperonesRNA, MessengerSeverity of Illness IndexYoung AdultAdvanced Oxidation Protein ProductsBiomarkersC1GALT1C1 protein, humanImmunoglobulin AMolecular ChaperonesRNA, MessengerCosmcgalactose-deficient IgA1Henoch-Schonlein purpuraperipheral B lymphocytesserum AOPPs

Identifiers

PMID31250447
PMCPMC6852516
OpenAlexW2955710463

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.