Evidence map›Paper›PMID 31250227›Full record

ArticleThe European physical journal. E, Soft matter2019

A comparison of ion channel current blockades caused by individual poly(ethylene glycol) molecules and polyoxometalate nanoclusters.

Haiyan Wang, John J Kasianowicz, Joseph W F Robertson, Dianne L Poster, Jessica Ettedgui

Abstract read
PubMed Publisher
In one paragraph

Article in The European physical journal. E, Soft matter, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Haiyan WangNational Institute of Standards and Technology, Physical Measurement Laboratory, 20899, Gaithersburg, MD, USA.
John J KasianowiczNational Institute of Standards and Technology, Physical Measurement Laboratory, 20899, Gaithersburg, MD, USA. john.kasianowicz@nist.gov.
Joseph W F RobertsonNational Institute of Standards and Technology, Physical Measurement Laboratory, 20899, Gaithersburg, MD, USA.
Dianne L PosterNational Institute of Standards and Technology, Material Measurement Laboratory, 20899, Gaithersburg, MD, USA.
Jessica EttedguiNational Institute of Standards and Technology, Physical Measurement Laboratory, 20899, Gaithersburg, MD, USA.
Physical Measurement Laboratory · USNational Institute of Standards and Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteinaceous nanometer-scale pores have been used to detect and physically characterize many different types of analytes at the single-molecule limit. The method is based on the ability to measure the transient reduction in the ionic channel conductance caused by molecules that partition into the pore. The distribution of blockade depth amplitudes and residence times of the analytes in the pore are used to physically and chemically characterize them. Here we compare the current blockade events caused by flexible linear polymers of ethylene glycol (PEGs) and structurally well-defined tungsten polyoxymetallate nanoparticles in the nanopores formed by Staphylococcus aureusα-hemolysin and Aeromonas hydrophila aerolysin. Surprisingly, the variance in the ionic current blockade depth values for the relatively rigid metallic nanoparticles is much greater than that for the flexible PEGs, possibly because of multiple charged states of the polyoxymetallate clusters.

Indexed as

Polymers: From Adsorption to Translocation - Topical Issue in Memoriam Loïc Auvray (1956-2016)

Identifiers

PMID31250227
OpenAlexW2954098318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.