Evidence map›Paper›PMID 31250201›Full record

ArticleVirchows Archiv : an international journal of pathology2019

Comparative genome-wide analysis of gastric adenocarcinomas with hyperplastic polyp components.

Yoshiyasu Takayama, Yusuke Ono, Yusuke Mizukami, Hideaki Itoh, Nozomi Nakajima, Hideo Arai, Shinya Tanaka, Sumihito Nobusawa, Hideaki Yokoo, Yasuhiro Onozato

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Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yoshiyasu TakayamaDepartment of Pathology, Gunma University Hospital, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. m13702004@gunma-u.ac.jp.ORCID http://orcid.org/0000-0003-4876-3413
Yusuke OnoInstitute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
Yusuke MizukamiInstitute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
Hideaki ItohDepartment of Pathology, Keiaido Hospital, Maebashi, Japan.
Nozomi NakajimaDepartment of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Hideo AraiDepartment of Pathology, Gunma University Hospital, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Shinya TanakaDepartment of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Sumihito NobusawaDepartment of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Hideaki YokooDepartment of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Yasuhiro OnozatoDepartment of Endoscopy and Endoscopic Surgery, Shirakawa Clinic, Maebashi, Japan.
Gunma University · JPGunma University Hospital · JPAsahikawa Medical University · JPHokkaido University · JPSapporo Higashi Tokushukai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric hyperplastic polyps are common and generally regarded as benign lesions, whereas gastric adenocarcinomas infrequently occur from gastric hyperplastic polyps. Although gastric hyperplastic polyps have received a lot of attention because of their association with malignant transformation, it remains unclear whether gastric hyperplastic polyps are neoplastic lesions that have sporadic genetic changes similar to colorectal hyperplastic polyps. We performed genome-wide analyses of two gastric adenocarcinomas with hyperplastic polyp components. The interface between "adenocarcinoma" and "hyperplastic polyp" components was fairly sharp, and the adenocarcinoma components had copy number alterations and TP53 mutations, whereas the hyperplastic polyp components had only single nucleotide polymorphisms, which were also found in adenocarcinoma components. We did not detect any somatic changes in the hyperplastic polyp components, even in genome-wide analyses, which was in contrast to the adenocarcinoma components. However, due to the small number of cases examined herein, further genetic analyses of more cases are needed.

Indexed as

AdenocarcinomaAdenomatous PolypsAgedAged, 80 and overCell Transformation, NeoplasticComparative Genomic HybridizationDNA Copy Number VariationsFemaleGenome-Wide Association StudyHumansHyperplasiaIntestinal PolypsPolymorphism, Single NucleotidePolypsStomach NeoplasmsTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53AdenocarcinomaArray comparative genomic hybridizationHyperplastic polypMalignant transformationTargeted amplicon sequencing

Identifiers

PMID31250201
OpenAlexW2954384510

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.