Evidence map›Paper›PMID 31250199›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2019

Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs.

Sheba Plamthottam, Daniel Sun, Juno Van Valkenburgh, Jeffrey Valenzuela, Bastian Ruehle, Dalton Steele, Soumya Poddar, Maxim Marshalik, Selena Hernandez, Caius Gabriel Radu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Transmetalation in Cancer Pharmacology.International journal of molecular sciences · 2025
    Review
  3. Disulfide-based 2-pyridyl-hydrazone prochelators induce iron deprivation and oxidative stress in ovarian cancer cells.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sheba PlamthottamDepartment of Chemistry, University of California, Los Angeles, CA, 90095, USA.
Daniel Sun *Department of Chemistry, University of California, Los Angeles, CA, 90095, USA.
Juno Van Valkenburgh *Department of Chemistry, University of California, Los Angeles, CA, 90095, USA.
Jeffrey ValenzuelaDepartment of Chemistry, University of California, Los Angeles, CA, 90095, USA.
Bastian RuehleDepartment of Chemistry, University of California, Los Angeles, CA, 90095, USA.
Dalton SteeleDepartment of Chemistry, University of California, Los Angeles, CA, 90095, USA.
Soumya PoddarDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA.
Maxim MarshalikDepartment of Chemistry, University of California, Los Angeles, CA, 90095, USA.
Selena HernandezDepartment of Chemistry, University of California, Los Angeles, CA, 90095, USA.
Caius Gabriel RaduDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA.
Jeffrey I ZinkDepartment of Chemistry, University of California, Los Angeles, CA, 90095, USA. zink@chem.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Triapine (3-AP), is an iron-binding ligand and anticancer drug that is an inhibitor of human ribonucleotide reductase (RNR). Inhibition of RNR by 3-AP results in the depletion of dNTP precursors of DNA, thereby selectively starving fast-replicating cancer cells of nucleotides for survival. The redox-active form of 3-AP directly responsible for inhibition of RNR is the Fe(II)(3-AP)

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationCoordination ComplexesElectrochemistryEnzyme InhibitorsHumansIronMolecular StructureOxidation-ReductionPyridinesRibonucleotide ReductasesThiosemicarbazonesTyrosine3-aminopyridine-2-carboxaldehyde thiosemicarbazoneAntineoplastic AgentsCoordination ComplexesEnzyme InhibitorsIronPyridinesRibonucleotide ReductasesThiosemicarbazonesTyrosineAnticancer drugElectrochemistryLigand bindingRedox chemistryThiosemicarbazone metal complexes

Identifiers

PMID31250199
PMCPMC7849610
OpenAlexW2954537124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.