Evidence map›Paper›PMID 31250157›Full record

ArticleBrain structure & function2019

Localization of amyloid beta peptides to locus coeruleus and medial prefrontal cortex in corticotropin releasing factor overexpressing male and female mice.

Jennifer A Ross, Rody Alexis, Beverly A S Reyes, Victoria Risbrough, Elisabeth J Van Bockstaele

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jennifer A RossDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, 245 S. 15th Street, Philadelphia, PA, 19102, USA. jar485@drexel.edu.ORCID http://orcid.org/0000-0003-2167-1594
Rody AlexisDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, 245 S. 15th Street, Philadelphia, PA, 19102, USA.
Beverly A S ReyesDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, 245 S. 15th Street, Philadelphia, PA, 19102, USA.
Victoria RisbroughDepartment of Psychiatry, University of California, San Diego, CA, 92093, USA.
Elisabeth J Van BockstaeleDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, 245 S. 15th Street, Philadelphia, PA, 19102, USA.
Drexel University · USUniversity of California San Diego · US

Funding

OPIOID MODULATION OF THE COERULEO-CORTICAL PATHWAYR01DA009082 · NIDA · THOMAS JEFFERSON UNIVERSITY · PI VAN BOCKSTAELE, ELISABETH J · 2001 to 2017
$6.0M
Developing rodent models of PTSD/AUD: leveraging clinic-based strategiesR01AA026560 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DER-AVAKIAN, ANDRE, RISBROUGH, VICTORIA B · 2017 to 2021
$1.2M
Norepinephrine: A Novel Regulator of Amyloid Beta-42 PeptidesR21AG058263 · NIA · DREXEL UNIVERSITY · PI THOMAS, STEVEN A, VAN BOCKSTAELE, ELISABETH J · 2018 to 2019
$458k
BLRD VA I01 BX004312NIAAA NIH HHS R01 AA026560NIA NIH HHS R21 AG058263NIA NIH HHS R21 AG058263-01A1NIDA NIH HHS R01 DA009082
6 · The paper itself

Abstract

A culmination of evidence from the literature points to the Locus Coeruleus (LC)-Norepinephrine system as an underappreciated and understudied area of research in the context of Alzheimer's Disease (AD). Stress is a risk factor for developing AD, and is supported by multiple clinical and preclinical studies demonstrating that amplification of the stress system disrupts cellular and molecular processes at the synapse, promoting the production and accumulation of the amyloid beta (Aβ

Indexed as

Adrenergic NeuronsAmyloid beta-PeptidesAnimalsCorticotropin-Releasing HormoneFemaleLocus CoeruleusMaleMiceNorepinephrinePrefrontal CortexReceptors, Corticotropin-Releasing HormoneAmyloid beta-PeptidesCorticotropin-Releasing HormoneNorepinephrineReceptors, Corticotropin-Releasing HormoneAdrenergic receptorsAmyloidDopamine-β-hydroxylaseNorepinephrineStress

Identifiers

PMID31250157
PMCPMC7371412
OpenAlexW2954197327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.