ArticleClinical research in cardiology : official journal of the German Cardiac Society2020
Association of heart failure duration with clinical prognosis in advanced heart failure.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A practical approach to the guideline-directed pharmacological treatment of heart failure with reduced ejection fraction.ESC heart failure · 2023Review
- Impact of right ventricular-pulmonary arterial coupling on clinical outcomes of tricuspid regurgitation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
- Early response of right-ventricular function to percutaneous mitral valve repair.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- Position Statement on Diagnosis and Treatment of Cardiac Amyloidosis - 2021.Arquivos brasileiros de cardiologia · 2021Article
- Optimizing diastolic pressure gradient assessment.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Prognostic impact of potassium levels in patients with ventricular tachyarrhythmias.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- A novel risk score to predict survival in advanced heart failure due to cardiac amyloidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the prognostic impact of heart failure (HF) duration in patients with advanced HF.
methodsA total of 109 consecutive patients with advanced HF referred to the institutional heart transplant program between July 2014 and December 2017 were prospectively enrolled. The patients were divided into two groups according to the HF duration using a pre-specified cutoff (> 18 months, n = 38; ≤ 18 months, n = 71). The Cox proportional hazards model was generated to investigate the association between the HF duration and a 1-year composite endpoint (all-cause mortality, left ventricular assist device implantation, and hospitalization due to HF).
resultsPatients with a longer HF duration were older and had significantly lower blood pressure, and greater left ventricular volume compared with those with a shorter HF duration. The 1-year event-free survival rate was significantly lower in patients with a longer HF duration (49.1% vs. 80.0%, log-rank p < 0.001). After adjustment, a longer HF duration was independently associated with an increased risk for the composite endpoint (hazard ratio, 2.44; 95% confidence interval, 1.03-5.76; p = 0.04). Additionally, longer HF duration was independently associated with an increased wall motion score index and a decreased heart-to-mediastinum ratio of
conclusionsA longer HF duration is associated with an increased risk of adverse outcomes as well as more severe myocardial damage among patients with advanced HF.
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