ArticlePsychopharmacology2019
CB1 receptor antagonism in capuchin monkeys alters social interaction and aversive memory extinction.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons.Acta pharmacologica Sinica · 2025Article
- Combinatorial approaches for treating neuropsychiatric social impairment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
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Authors and funding
7 authors at 2 institutions in 4 countries.
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Abstract
rationaleThe endocannabinoid system (eCS) is an important modulator of social anxiety and social reward, as well as memory functions.
objectivesThe present study evaluated the role of eCS in social interactions and aversive memory extinction in capuchin monkeys (Sapajus spp.) by blocking the cannabinoid type 1 receptor (CB
methodsIn experiment 1, spontaneous social and non-social behaviors of five capuchin males, each one living in triads with two other females, were observed after AM251 treatment (vehicle, 0.3, 1.0, and 3.0 mg/kg; i.m.). In experiment 2, seven male capuchin monkeys were trained to reach for a reward inside a wooden box. After training, they were given either vehicle or a 3.0-mg/kg i.m. dose of AM251 before a single aversive encounter with a live snake in the box. The latency to return to reach the reward inside the box in subsequent trials was measured.
resultsThe 3.0-mg/kg dose significantly increased the time spent performing self-directed behaviors, while decreasing that of social interactions. No changes were observed in vigilance or locomotion. AM251 increased the latency to reach the reward after the aversive encounter.
conclusionTaken together, these results suggest that CB
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