ArticleArchives of toxicology2019
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
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Article in Archives of toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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45citing papers in PubMed, 1 pooled it
16.9field-weighted citation impact, top 1% of its field
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Exploring the potential of computer simulation models in drug testing and biomedical research: a systematic review.Frontiers in pharmacology · 2025Pooled it
- Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis.Drugs in R&D · 2023Trial
- Machine Learning-Based Models to Predict Drug-Induced Liver Injury (DILI) to Assist Medicinal Chemistry.Journal of medicinal chemistry · 2026Review
- Integration of in vitro and in silico approaches enables prediction of drug-induced liver injury.Archives of toxicology · 2026Article
- Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis.Archives of toxicology · 2026Review
- The PrecisionTox chemical library: creation of a chemical collection to discover evolutionary conserved biomolecular signatures of toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- A large-scale human toxicogenomics resource for drug-induced liver injury prediction.Nature communications · 2025Article
- Adjustment for day-to-day variability in the estimation of effective concentrations for the assessment of mixture toxicity.Archives of toxicology · 2025Article
- Design of optimal concentrations for in vitro cytotoxicity experiments.Archives of toxicology · 2025Article
- A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity.Archives of toxicology · 2024Article
- An original donor-dependent spheroid system for the prediction of idiosyncratic drug-induced liver injury risk.In vitro models · 2023Article
- Chemistry-Based Modeling on Phenotype-Based Drug-Induced Liver Injury Annotation: From Public to Proprietary Data.Chemical research in toxicology · 2023Article
- Pluripotent Stem Cell-Derived Hepatocyte-like Cells: Induction Methods and Applications.International journal of molecular sciences · 2023Review
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- Genotype-guided model significantly improves accuracy of tacrolimus initial dosing after liver transplantation.EClinicalMedicine · 2023Article
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- Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology.Communications medicine · 2022Article
- Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test.Chemical research in toxicology · 2022Article
- Research Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives.Drug design, development and therapy · 2022Review
- Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.Archives of toxicology · 2021Article
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Authors and funding
48 authors at 20 institutions in 10 countries.
Wiebke Albrecht *Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. albrecht@ifado.de.
Franziska Kappenberg *Department of Statistics, TU Dortmund University, 44227, Dortmund, Germany.
Tim Brecklinghaus *Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Regina StoeberLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Rosemarie MarchanLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Mian ZhangSimcyp (A Certara Company), Sheffield, UK.
Kristina EbbertLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Hendrik KirschnerLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Marianna GrinbergDepartment of Statistics, TU Dortmund University, 44227, Dortmund, Germany.
Marcel LeistIn Vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Universitätsstr. 10, PO Box M657, 78457, Constance, Germany.
Wolfgang MoritzInSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland.
Cristina CadenasLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Ahmed GhallabLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Jörg ReindersLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Nachiket VartakLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Christoph van ThrielLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Klaus GolkaLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Laia TolosaExperimental Hepatology Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
José V CastellExperimental Hepatology Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
Georg DammDepartment of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353, Berlin, Germany.
Daniel SeehoferDepartment of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353, Berlin, Germany.
Alfonso LampenDepartment Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Albert BraeuningDepartment Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Thorsten BuhrkeDepartment Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Anne-Cathrin BehrDepartment Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Axel OberemmDepartment Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Xiaolong GuCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, 650201, Yunnan, People's Republic of China.
Naim KittanaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, PO Box 7, Nablus, Palestine.
Bob van de WaterDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, PO Box 9502, 2300 RA, Leiden, The Netherlands.
Reinhard KreilingClariant Produkte (Deutschland) GmbH, Am Unisyspark 1, 65843, Sulzbach, Germany.
Susann FayyazClariant Produkte (Deutschland) GmbH, Am Unisyspark 1, 65843, Sulzbach, Germany.
Leon van AertsMedicines Evaluation Board: Pharmacology, Toxicology, Pharmacokinetics, Utrecht, The Netherlands.
Bård SmedsrødDepartment of Medical Biology, Vascular Biology Research Group, University of Tromsø, NO-9037, Tromsø, Norway.
Heidrun Ellinger-ZiegelbauerInvestigational Toxicology, Drug Discovery, Pharmaceuticals, Bayer AG, 42096, Wuppertal, Germany.
Thomas Steger-HartmannInvestigational Toxicology, Drug Discovery, Pharmaceuticals, Bayer AG, 42096, Wuppertal, Germany.
Ursula Gundert-RemyInstitute for Clinical Pharmacology and Toxicology, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Anja ZeigererInstitute for Diabetes and Cancer, Helmholtz Center Munich, 85764 Neuherberg, Germany and Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany.
Anett UllrichPrimacyt Cell Culture Technology GmbH, Schwerin, Germany.
Dieter RungePrimacyt Cell Culture Technology GmbH, Schwerin, Germany.
Serene M L LeeBiobank Under the Administration of the Human Tissue and Cell Research Foundation, Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
Tobias S SchiergensBiobank Under the Administration of the Human Tissue and Cell Research Foundation, Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
Lars KuepferSystems Pharmacology, Bayer AG, Leverkusen, Germany.
Alejandro Aguayo-OrozcoTranslational Disease Systems Biology, NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Agapios SachinidisInstitute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne (UKK), Robert-Koch-Str. 39, 50931, Cologne, Germany.
Karolina EdlundLeibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.
Iain Gardner *Simcyp (A Certara Company), Sheffield, UK.
Jörg Rahnenführer *Department of Statistics, TU Dortmund University, 44227, Dortmund, Germany.
Jan G Hengstler *Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. hengstler@ifado.de.
Leibniz Research Centre for Working Environment and Human Factors · DETU Dortmund University · DEFederal Institute for Risk Assessment · DEBayer (Germany) · DECharité - Universitätsmedizin Berlin · DEClariant (Germany) · DEInstituto de Investigación Sanitaria La Fe · ESSimcyp (United Kingdom) · GBAn-Najah National University · PSBiomedical Research Foundation · BDCentre for Human Drug Research · NLDeutsches Diabetes-Zentrum e.V. · DELeipzig University · DELudwig-Maximilians-Universität München · DEMedicines Evaluation Board · NLSouth Valley University · EGUiT The Arctic University of Norway · NOUniversity of Cologne · DEUniversity of Copenhagen · DKUniversity of Konstanz · DE
Funding
BMBF 01EK1604ABMBF 031L0021ABMBF 031L0045BMBF 031LO119EU 116030EU 681002European Regional Development Fund CP16/00097
Abstract
Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To overcome this limitation, an in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations. This method can be used to estimate DILI risk if the maximal blood concentration (C
Indexed as
Administration, OralAlgorithmsAnimalsCell LineCell SurvivalChemical and Drug Induced Liver InjuryComputer SimulationDrug-Related Side Effects and Adverse ReactionsGene ExpressionHepatocytesHumansIn Vitro TechniquesMaximum Tolerated DosePharmaceutical PreparationsPharmacokineticsReproducibility of ResultsPharmaceutical Preparations3D cultureAlternative methodsCryopreservedCultivated hepatocytesHepatotoxicityPerformance metrics
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