ReviewApplied microbiology and biotechnology2019
Multi-level regulation of coelimycin synthesis in Streptomyces coelicolor A3(2).
Review in Applied microbiology and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- γ-Butyrolactone-induced coelimycin synthesis inhibits AtrA-dependent actinorhodin overproduction inmBio · 2026Article
- Salt supplementation-induced metabolic reprogramming inmSystems · 2026Article
- The regulatory role of histidine kinase in modulating nucleoside metabolites inFrontiers in microbiology · 2026Article
- Overexpression of Scr1 protein induces strong changes in the transcriptome and metabolome of Streptomyces coelicolor that affect antibiotic production.Microbial cell factories · 2025Article
- Study on the regulatory mechanism of NsdAMicrobial cell factories · 2025Article
- Unveiling novel features and phylogenomic assessment of indigenousMicrobiology spectrum · 2025Article
- Coelimycin inside out - negative feedback regulation by its intracellular precursors.Applied microbiology and biotechnology · 2024Article
- Changing the Inoculum Type From Preculture to Spore Suspension Markedly Alters the Production of Secondary Metabolites in Filamentous Microbial Coculture.Current microbiology · 2024Article
- Global regulator AdpA directly binds to tunicamycin gene cluster and negatively regulates tunicamycin biosynthesis in Streptomyces clavuligerus.World journal of microbiology & biotechnology · 2024Article
- Functional connexion of bacterioferritin in antibiotic production and morphological differentiation in Streptomyces coelicolor.Microbial cell factories · 2024Article
- Consequences of the deletion of the major specialized metabolite biosynthetic pathways of Streptomyces coelicolor on the metabolome and lipidome of this strain.Microbial biotechnology · 2024Article
- Trends in the two-component system's role in the synthesis of antibiotics by Streptomyces.Applied microbiology and biotechnology · 2023Review
- Evolution of genome fragility enables microbial division of labor.Molecular systems biology · 2023Article
- A TetR family transcriptional regulator, SP_2854 can affect the butenyl-spinosyn biosynthesis by regulating glucose metabolism in Saccharopolyspora pogona.Microbial cell factories · 2022Article
- Carbon catabolite regulation of secondary metabolite formation, an old but not well-established regulatory system.Microbial biotechnology · 2022Review
- Curation, inference, and assessment of a globally reconstructed gene regulatory network for Streptomyces coelicolor.Scientific reports · 2022Article
- Proteomining-Based Elucidation of Natural Product Biosynthetic Pathways inFrontiers in microbiology · 2022Article
- GntR-like SCO3932 Protein Provides a Link between Actinomycete Integrative and Conjugative Elements and Secondary Metabolism.International journal of molecular sciences · 2021Article
- A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of aMicroorganisms · 2021Article
- A comparative metabologenomic approach reveals mechanistic insights intoProceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite being a yellow pigment visible to the human eye, coelimycin (CPK) remained to be an undiscovered secondary metabolite for over 50 years of Streptomyces research. Although the function of this polyketide is still unclear, we now know that its "cryptic" nature is attributed to a very complex and precise mechanism of cpk gene cluster regulation in the model actinomycete S. coelicolor A3(2). It responds to the stringent culture density and timing of the transition phase by the quorum-sensing butanolide system and to the specific nutrient availability/uptake signals mediated by the global (pleiotropic) regulators; many of which are two-component signal transduction systems. The final effectors of this regulation cascade are predicted to be two cluster-situated Streptomyces antibiotic regulatory proteins (SARPs) putatively activating the expression of type I polyketide synthase (PKS I) genes. After its synthesis, unstable, colorless antibiotic coelimycin A reacts with specific compounds in the medium losing its antibacterial properties and giving rise to yellow coelimycins P1 and P2. Here we review the current knowledge on coelimycin synthesis regulation in Streptomyces coelicolor A3(2). We focus on the regulatory feedback loop which interconnects the butanolide system with other cpk cluster-situated regulators. We also present the effects exerted on cpk genes expression by the global, pleiotropic regulators, and the regulatory connections between cpk and other biosynthetic gene clusters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.