ReviewTH open : companion journal to thrombosis and haemostasis2018
Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review.
Review in TH open : companion journal to thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06694090 (Von Willebrand Factor Levels in Patients With Liver Cirrhosis and Portal Hypertension), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Von Willebrand Factor Levels in Patients With Liver Cirrhosis and Portal Hypertension
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Thrombin generation abnormalities in Quebec platelet disorder.International journal of laboratory hematology · 2020Trial
- The relationships between disseminated intravascular coagulation and time series change of Von Willebrand factor in patients with out-of-hospital cardiac arrest: a retrospective observational study.Thrombosis journal · 2026Article
- Platelet recruitment kinetics are impacted by von Willebrand factor quality in hemostatic adjuncts.Blood vessels, thrombosis & hemostasis · 2025Article
- A Disintegrin and Metalloprotease with Thrombospondin Motif, Member 13, and Von Willebrand Factor in Relation to the Duality of Preeclampsia and HIV Infection.International journal of molecular sciences · 2025Review
- Von Willebrand factor processing in patients with advanced chronic liver disease and its relation to portal hypertension and clinical outcome.Hepatology international · 2023Article
- Tranexamic acid for haemostasis and beyond: does dose matter?Thrombosis journal · 2023Review
- Blood Clotting Dissolution in the Presence of a Magnetic Field and Preliminary Study with MG63 Osteoblast-like Cells-Further Developments for Guided Bone Regeneration?Bioengineering (Basel, Switzerland) · 2023Article
- Plasmin-Induced Lens Epithelial Cells Detachment for the Reduction of Posterior Capsular Opacification.Translational vision science & technology · 2023Article
- ADAMTS13 Activity Measurement by ELISA and Fluorescence Resonance Energy Transfer Assay.Methods in molecular biology (Clifton, N.J.) · 2023Article
- ADAMTS13 Activity: Screening Test Protocol.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Review
- Role of Plasminogen Activation System in Platelet Pathophysiology: Emerging Concepts for Translational Applications.International journal of molecular sciences · 2022Review
- Assessing Plasmin Generation in Health and Disease.International journal of molecular sciences · 2021Review
- Quantitatively monitoring acute ischemic stroke patients post recombinant tissue plasminogen activator treatment.Health science reports · 2021Article
- Therapeutic Potentials ofLife (Basel, Switzerland) · 2021Article
- Review
- S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity.PLoS neglected tropical diseases · 2021Article
- Improved platelet counts during prolonged tranexamic therapy for Quebec platelet disorder implicate the underlying fibrinolytic defect as the cause of lower platelet counts.International journal of laboratory hematology · 2020Article
- Plasmin-Induced Activation of Human Platelets Is Modulated by Thrombospondin-1, Bona Fide Misfolded Proteins and Thiol Isomerases.International journal of molecular sciences · 2020Article
- COVID-19 update: Covid-19-associated coagulopathy.Journal of thrombosis and thrombolysis · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von Willebrand factor (VWF) multimers and (2) as an activator of platelets. Although the molecular mechanisms of fibrinolysis are well defined, insights on the effects of plasmin on VWF and platelets are relatively scarce and sometimes conflicting. Hence, this review provides an overview of the literature on the effects of plasmin on VWF multimeric structures, on VWF binding to platelets, and on platelet activation. This information is placed in the context of possible applications of thrombolytic therapy for the condition thrombotic thrombocytopenic purpura.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.