ArticleTH open : companion journal to thrombosis and haemostasis2018
Evaluation of the DOAC-Stop® Procedure to Overcome the Effect of DOACs on Several Thrombophilia Screening Tests.
Article in TH open : companion journal to thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Usefulness and Limits of DOAC Removal Agents Based on Activated Charcoal in Thrombophilia Testing: Literature Review and Expert Proposals.Thrombosis and haemostasis · 2026Review
- Direct oral anticoagulant interference and removal in the factor VIII inhibitor assay.Research and practice in thrombosis and haemostasis · 2026Article
- Impact of asundexian on a panel of coagulation assays.Research and practice in thrombosis and haemostasis · 2025Article
- Is lupus anticoagulant testing with dilute Russell's viper venom clotting times reliable in the presence of inflammation?Research and practice in thrombosis and haemostasis · 2024Article
- Simplified Method for Removing Direct Oral Anticoagulant Interference in Mechanical Coagulation Test Systems-A Proof of Concept.Journal of clinical medicine · 2024Article
- Comparing the Effect of DOAC-StopBritish journal of biomedical science · 2024Article
- Article
- The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review.Thrombosis journal · 2023Review
- Novel Ex Vivo DOAC Removal Methods Reduce Interference in Lupus Anticoagulant Testing.Diagnostics (Basel, Switzerland) · 2022Article
- Effect on Plasma Protein S Activity in Patients Receiving the Factor Xa Inhibitors.Journal of atherosclerosis and thrombosis · 2022Article
- Inherited Thrombophilia in the Era of Direct Oral Anticoagulants.International journal of molecular sciences · 2022Review
- Lupus anticoagulant testing during anticoagulation, including direct oral anticoagulants.Research and practice in thrombosis and haemostasis · 2022Review
- Direct Oral Anticoagulant removal by a DOAC filter: Impact on lupus anticoagulant testing - Evaluation on spiked and patient samples.Research and practice in thrombosis and haemostasis · 2022Article
- Recent Advances in Anticoagulant Treatment of Immune Thrombosis: A Focus on Direct Oral Anticoagulants in Heparin-Induced Thrombocytopenia and Anti-Phospholipid Syndrome.International journal of molecular sciences · 2021Review
- Direct oral anticoagulant (DOAC) interference in hemostasis assays.Hematology. American Society of Hematology. Education Program · 2021Article
- Evaluation of the Determination of Dabigatran, Rivaroxaban, and Apixaban in Lupus Anticoagulant-Positive Patients.Diagnostics (Basel, Switzerland) · 2021Article
- 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
- What Do We Know about Thromboprophylaxis and Its Monitoring in Critically Ill Patients?Biomedicines · 2021Review
- Management of an acute cerebral embolic infarct with thrombolysis and mechanical thrombectomy in the presence of an aortic arch floating thrombus.BMJ case reports · 2021Article
- Updates in Anticoagulation Therapy Monitoring.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of direct oral anticoagulants (DOACs) on laboratory assays used for thrombophilia testing (e.g., antithrombin, protein S, protein C, lupus anticoagulant and activated protein-C resistance) is a well-known issue and may cause false-positive and -negative results. Therefore, the correct interpretation of tests that are performed in patients taking DOACs is mandatory to prevent misclassification and the subsequent clinical consequences. We aimed at evaluating the efficiency of a new and simple procedure (DOAC-Stop®; Haematex Research, Hornsby, Australia) to overcome the effect of all DOACs in real-life settings and to assess the percentage of erroneous results due to the presence of DOACs on thrombophilia screening tests. For this purpose, 135 DOAC-treated patients (38 apixaban, 40 dabigatran, 15 edoxaban, and 42 rivaroxaban) and 20 control patients were enrolled. A significant drop in apixaban, dabigatran, edoxaban, and rivaroxaban plasma concentrations following the DOAC-Stop® treatment was observed (74.8-8.2 ng/mL [
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