ArticleScience advances2019
Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.
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Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Ovarian Tissue Transplantation Outcomes by Ovarian Tissue Processing Size for Cryopreservation.Frontiers in endocrinology · 2022Pooled it
- Stepwise pairing and fast transition regulated by recombination drive meiotic chromosome interactions.Nature communications · 2026Article
- Mechanics of compression-driven morphogenesis.Development (Cambridge, England) · 2026Review
- Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve.Nature aging · 2026Article
- Ovarian Extracellular Matrix Mechanics Regulate Oocyte-Follicle Interactions During Female Reproductive Aging.Aging cell · 2026Article
- Modulating IL-11-dependent matrix stiffness to delay ovarian aging.Nature aging · 2026Article
- Dynamic blebbing and absence of organelle transfer during mouse oocyte formation.The EMBO journal · 2026Article
- Gene regulatory networks orchestrating oocyte fate bifurcation in primordial follicles revealed by single-cell transcriptomics.Communications biology · 2026Article
- Ovarian Matrisome Dynamics and αvβ3-Mediated Regulation in Early Follicular Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Changes in ovarian hardness and elasticity affect the development and function of secondary follicles.Scientific reports · 2026Article
- The intrinsic impact of mechanical stress on the maintenance of oocyte dormancy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Macrophages and immunometabolism in diminished ovarian reserve: pathological features and therapeutic implications.Frontiers in endocrinology · 2026Review
- Forceful Beginnings: Mechanotransduction and Mechanosensation at the Meiotic Cell Nucleus During Gamete Development.Results and problems in cell differentiation · 2026Review
- Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis.Advanced biology · 2026Article
- In Vitro Development of Primordial Follicles from Human Ovarian Tissue.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Neonatal Mouse Ovary Culture and Whole-mount Follicle Quantification: An Efficient In Vitro Approach for Studying Primordial Follicle Regulation.Journal of visualized experiments : JoVE · 2025Article
- Evaluating Selective Quality Control in Mammalian Oogenesis: Evidence and Opportunities.Annual review of genetics · 2025Review
- Elevated hydrostatic pressure dysregulates lipid metabolism of hepatocytes.Journal of physiology and biochemistry · 2025Article
- Surface mechanics and compressive stress impact mammalian follicle development.Nature communications · 2025Article
- Three-dimensional quantitative micro-elastography reveals alterations in spatial elasticity patterns in murine ovaries during ageing.Communications biology · 2025Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most immature oocytes remain dormant in primordial follicles in the ovary, ensuring the longevity of female reproductive life. Despite its biological and clinical importance, knowledge of mechanisms regulating the dormant state remains limited. Here, we show that mechanical stress plays a key role in maintaining the dormant state of the oocytes in primordial follicles in mice. Transcriptional and histological analyses revealed that oocytes were compressed by surrounding granulosa cells with extracellular matrix. This environmental state is functionally crucial, as oocytes became activated upon loosening the structure and the dormancy was restored by additional compression with exogenous pressure. The nuclei of oocytes in primordial follicles rotated in response to the mechanical stress. Pausing the rotation triggered activation of oocytes through nuclear export of forkhead box O3 (FOXO3). These results provide insights into the mechanisms by which oocytes are kept dormant to sustain female reproductive life.
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