ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Diagnosing neurodegenerative disorders using retina as an external window: A systematic review of OCT-MRI correlations.Journal of Alzheimer's disease : JAD · 2025Pooled it
- A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images.Journal of Alzheimer's disease reports · 2023Pooled it
- Association between retinal markers and cognition in older adults: a systematic review.BMJ open · 2022Pooled it
- Optical Coherence Tomography in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Review
- Differentiating Alzheimer's disease and vascular dementia via combined OCT and OCT‑angiography analysis.Scientific reports · 2026Article
- Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Retinal microvascular alterations in Alzheimer's disease: Linking blood plasma biomarkers and cerebral small vessel pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Retinal microstructure and microvasculature in association with brain amyloid burden.Brain communications · 2025Article
- Multimodal photoacoustic microscopy and optical coherence tomography ocular biomarker imaging in Alzheimer's disease in mice.Biomedical optics express · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Choriocapillaris reduction accurately discriminates against early-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Eye Adult Changes in Thought (Eye ACT) Study: Design and Report on the Inaugural Cohort.Journal of Alzheimer's disease : JAD · 2024Article
- Retinal Alterations as Potential Biomarkers of Structural Brain Changes in Alzheimer's Disease Spectrum Patients.Brain sciences · 2023Article
- Machine learning based on Optical Coherence Tomography images as a diagnostic tool for Alzheimer's disease.CNS neuroscience & therapeutics · 2022Article
- The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals.Alzheimer's research & therapy · 2022Article
- Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.International journal of molecular sciences · 2022Review
- Past, present and future role of retinal imaging in neurodegenerative disease.Progress in retinal and eye research · 2021Review
- Retinal microvasculature dysfunction is associated with Alzheimer's disease and mild cognitive impairment.Alzheimer's research & therapy · 2020Article
- Commentary: Viewing Alzheimer's disease from an ophthalmologist's eyes.Indian journal of ophthalmology · 2020Article
Corrections and comments
- Erratum issuedErratum.2020 · Haan, Jurre Den [corrected to den Haan, Jurre]; Kate, Mara Ten [corrected to ten Kate, Mara]; Braber, Anouk Den [corrected to den Braber, Anouk]
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Retinal thickness measured with optical coherence tomography has been proposed as a noninvasive biomarker for Alzheimer's disease (AD). We therefore measured retinal thickness in well-characterized AD and control participants, considering ophthalmological confounders. Methods: We included 57 amyloid-proven AD cases and 85 cognitively normal, amyloid-negative controls. All subjects underwent retinal thickness measurements with spectral domain optical coherence tomography and an ophthalmological assessment to exclude ocular disease. Results: Retinal thickness did not discriminate cases from controls, including stratified analyses for early- versus late-onset AD. We found significant associations between macular thickness and global cortical atrophy [β -0.358; Discussion: In this study, representing the largest optical coherence tomography cohort with amyloid-proven AD cases, we show that retinal thickness does not discriminate AD from controls, despite evident changes on clinical, neuroimaging, and CSF measures, querying the use of retinal thickness measurements as an AD biomarker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.