Evidence map›Paper›PMID 31249786›Full record

ArticleToxicology reports2019

Glucocorticoid receptor-dependent induction of

Michael A Garland, Sumitra Sengupta, Lijoy K Mathew, Lisa Truong, Esther de Jong, Aldert H Piersma, Jane La Du, Robert L Tanguay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Inhibition of Fin Regeneration in Fathead Minnow (Environmental science & technology · 2025
    Article
  3. Article
  4. Review
  5. Environmental mechanisms of orofacial clefts.Birth defects research · 2020
    Review
  6. Alternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration model.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Michael A GarlandDepartment of Environmental and Molecular Toxicology, United States.
Sumitra SenguptaDepartment of Environmental and Molecular Toxicology, United States.
Lijoy K MathewDepartment of Environmental and Molecular Toxicology, United States.
Lisa TruongDepartment of Environmental and Molecular Toxicology, United States.
Esther de JongInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Aldert H PiersmaInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Jane La DuDepartment of Environmental and Molecular Toxicology, United States.
Robert L TanguayDepartment of Environmental and Molecular Toxicology, United States.
Society of Environmental Toxicology and Chemistry · USNational Institute for Public Health and the Environment · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously used a chemical genetics approach with the larval zebrafish to identify small molecule inhibitors of tissue regeneration. This led to the discovery that glucocorticoids (GC) block early stages of tissue regeneration by the inappropriate activation of the glucocorticoid receptor (GR). We performed a microarray analysis to identify the changes in gene expression associated with beclomethasone dipropionate (BDP) exposure during epimorphic fin regeneration. Oncofetal

Indexed as

AEC, apical epithelial capBDP, beclomethasone dipropionateBeclomethasone dipropionateCripto-1DMSO, dimethyl sulfoxidedpa, days post-amputationdpf, days post-fertilizationEB, embryoid bodyECM, extracellular matrixEMT, epithelial-to-mesenchymal transitionEpimorphic regenerationERK, extracellular signal-regulated kinaseeSC, embryonic stem cellFGF, fibroblast growth factorGC, glucocorticoidGlucocorticoidsGR, glucocorticoid receptorhpa, hours post-amputationhpf, hours post-fertilizationISH, in situ hybridizationMIAME, Minimum Information About a Microarray ExperimentmLIF, murine leukemia inhibitory factorMO, morpholino oligonucleotideOne-eyed pinheadqRT-PCR, quantitative reverse transcription polymerase chain reactionRA, retinoic acidSEM, standard error of the meanTGF-β, transforming growth factor betaZebrafishzf, zebrafish

Identifiers

PMID31249786
PMCPMC6584771
OpenAlexW2947286264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.