Evidence map›Paper›PMID 31249650›Full record

ArticleOxidative medicine and cellular longevity2019

Multiorgan Development of Oxidative and Nitrosative Stress in LPS-Induced Endotoxemia in C57Bl/6 Mice: DHE-Based

Bartosz Proniewski, Agnieszka Kij, Barbara Sitek, Eric E Kelley, Stefan Chlopicki

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  8. SUPPRESION OF MITOCHONDRIAL RESPIRATION IS A FEATURE OF CELLULAR GLUCOSE TOXICITY.Transactions of the American Clinical and Climatological Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Bartosz ProniewskiJagiellonian University, Jagiellonian Centre for Experimetal Therapeutics (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland.ORCID 0000-0002-5138-1451
Agnieszka KijJagiellonian University, Jagiellonian Centre for Experimetal Therapeutics (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland.
Barbara SitekJagiellonian University, Jagiellonian Centre for Experimetal Therapeutics (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland.
Eric E KelleyDepartment of Physiology & Pharmacology, West Virginia University, Morgantown, WV 26506, USA.
Stefan ChlopickiJagiellonian University, Jagiellonian Centre for Experimetal Therapeutics (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland.ORCID 0000-0002-2878-3858
Jagiellonian University · PLWest Virginia University · US

Funding

West Virginia University Stroke COBREP20GM109098 · NIGMS · WEST VIRGINIA UNIVERSITY · PI HRUSKA, MARTIN · 2014 to 2024
$24.5M
NIGMS NIH HHS P20 GM109098
6 · The paper itself

Abstract

Detection of free radicals in tissues is challenging. Most approaches rely on incubating excised sections or homogenates with reagents, typically at supraphysiologic oxygen tensions, to finally detect surrogate, nonspecific end products. In the present work, we explored the potential of using intravenously (i.v.) injected dihydroethidine (DHE) to detect superoxide radical (O

Indexed as

Nitrosative StressOxidative StressAnimalsDicarbethoxydihydrocollidineEndotoxemiaInflammationLipopolysaccharidesLiverLungMaleMiceMice, Inbred C57BLNitric OxideOxidation-ReductionReactive Nitrogen SpeciesSuperoxidesDicarbethoxydihydrocollidinedihydroethidineLipopolysaccharidesNitric OxideReactive Nitrogen SpeciesSuperoxides

Identifiers

PMID31249650
PMCPMC6556324
OpenAlexW2945150329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.