ArticlePolymer chemistry2019
Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity.
Article in Polymer chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Directed Functionalization of Recombinant Spider Silk Nonwoven Membranes with Antibodies Using Non-Canonical Amino Acids.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Unlocking complexity through neutron scattering: Structure and dynamics of protein-polymer conjugates.Protein science : a publication of the Protein Society · 2025Review
- Self-Assembled Protein-Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly for Targeted and Enhanced Drug Delivery in Cancer Therapy.Molecules (Basel, Switzerland) · 2025Article
- Sequence-encoded bioactive protein-multiblock polymer conjugates via quantitative one-pot iterative living polymerization.Nature communications · 2024Article
- Comparison of Cyclic and Linear PEG Conjugates.Bioconjugate chemistry · 2024Article
- Tailored Branched Polymer-Protein Bioconjugates for Tunable Sieving Performance.ACS macro letters · 2024Article
- An organometallic swap strategy for bottlebrush polymer-protein conjugate synthesis.Chemical communications (Cambridge, England) · 2024Article
- Reversible Polymer-Protein Functionalization by Stepwise Introduction of Amine-Reactive, Reductive-Responsive Self-Immolative End Groups onto RAFT-Derived Polymers.ACS biomaterials science & engineering · 2024Article
- γ-Functional Iminiumthiolactones for the Single and Double Modification of Peptides.Bioconjugate chemistry · 2023Article
- Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems.ACS biomaterials science & engineering · 2023Review
- Conserved Protein-Polymer Interactions across Structurally Diverse Polymers Underlie Alterations to Protein Thermal Unfolding.ACS central science · 2023Article
- Polymer modification of SARS-CoV-2 spike protein impacts its ability to bind key receptor.European polymer journal · 2023Article
- Noncovalent Enzyme Nanogels via a Photocleavable Linkage.Macromolecules · 2022Article
- Preparation of Temperature-Responsive Antibody-Nanoparticles by RAFT-Mediated Grafting from Polymerization.Polymers · 2022Article
- Polynorbornene-based bioconjugates by aqueous grafting-from ring-opening metathesis polymerization reduce protein immunogenicity.Cell reports. Physical science · 2022Article
- A circular dichroism study of the protective role of polyphosphoesters polymer chains in polyphosphoester-myoglobin conjugates.Chirality · 2022Article
- Temperature Responsive Polymer Conjugate Prepared by "Grafting from" Proteins toward the Adsorption and Removal of Uremic Toxin.Molecules (Basel, Switzerland) · 2022Article
- Automated prediction of site and sequence of protein modification with ATRP initiators.PloS one · 2022Article
- How Various Drug Delivery Methods Could Aid in the Translation of Genome Prime Editing Technologies.Genetics research · 2022Review
- Hydrolytically Stable Maleimide-End-Functionalized Polymers for Site-Specific Protein Conjugation.Bioconjugate chemistry · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
For more than 40 years, protein-polymer conjugates have been widely used for many applications, industrially and biomedically. These bioconjugates have been shown to modulate the activity and stability of various proteins while introducing reusability and new activities that can be used for drug delivery, improve pharmacokinetic ability, and stimuli-responsiveness. Techniques such as RDRP, ROMP and "click" have routinely been utilized for development of well-defined bioconjugate and polymeric materials. Synthesis of bioconjugate materials often take advantage of natural amino acids present within protein and peptide structures for a host of coupling chemistries. Polymer modification may elicit increased or decreased activity, activity retention under harsh conditions, prolonged activity
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.