Evidence map›Paper›PMID 31249598›Full record

ArticleFrontiers in genetics2019

RNA Expression Profile and Potential Biomarkers in Patients With Spinocerebellar Ataxia Type 3 From Mainland China.

Tianjiao Li, Xiaocan Hou, Zhao Chen, Yun Peng, Puzhi Wang, Yue Xie, Lang He, Hongyu Yuan, Huirong Peng, Rong Qiu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. ACS chemical biology · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Tianjiao LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xiaocan HouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Zhao ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yun PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Puzhi WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yue XieDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lang HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hongyu YuanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Huirong PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Rong QiuSchool of Information Science and Engineering, Central South University, Changsha, China.
Kun XiaMedical Genetics Research Center, Central South University, Changsha, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) play an important role in growth, development, and reproduction and undoubtedly contribute to the pathogenesis and progression of diseases. Emerging evidence suggests the involvement of lncRNAs as regulatory factors in pathological conditions, including some neurodegenerative diseases. Spinocerebellar Ataxia Type 3/Machado-Joseph Disease (SCA3/MJD) has a prominent prevalence in China. Because the role of lncRNAs in SCA3/MJD pathogenesis has not yet been investigated, we conducted a pilot study to investigate the expression profile of lncRNAs by high-throughput sequencing in 12 patients and 12 healthy individuals. The sequencing analysis detected 5,540 known and 2,759 novel lncRNAs. Six lncRNAs were confirmed to be differentially expressed in peripheral blood mononuclear cells between SCA3/MJD patients and healthy individuals and were further validated in cerebellar tissue. Based on these results, NONHSAT022144.2 and NONHSAT165686.1 may be involved in the pathogenesis of SCA3/MJD and may be potential biomarkers for SCA3/MJD. Together with NONHSAT022144.2 and NONHSAT165686.1, the other four novel lncRNAs increase our understanding of lncRNA expression profile.

Indexed as

biomarkerexpression profilelong non-coding RNAsMachado–Joseph diseaseSpinocerebellar Ataxia Type 3

Identifiers

PMID31249598
PMCPMC6584761
OpenAlexW2949281772

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.