Evidence map›Paper›PMID 31249550›Full record

ArticleFrontiers in neurology2019

Temporal Lobe Cavernous Malformation Caused Epileptic Amnesic Episodes and Mild Cognitive Impairment.

Yusuke Hirokawa, Ayataka Fujimoto, Naoki Ichikawa, Keishiro Sato, Tokutaro Tanaka, Hideo Enoki, Yoshiro Otsuki, Tohru Okanishi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yusuke HirokawaDepartment of Neurosurgery, Seirei-Hamamatsu General Hospital, Hamamatsu, Japan.
Ayataka FujimotoComprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Japan.
Naoki IchikawaComprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Japan.
Keishiro SatoComprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Japan.
Tokutaro TanakaDepartment of Neurosurgery, Seirei-Hamamatsu General Hospital, Hamamatsu, Japan.
Hideo EnokiComprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Japan.
Yoshiro OtsukiDepartment of Pathology, Seirei-Hamamatsu General Hospital, Hamamatsu, Japan.
Tohru OkanishiComprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Japan.
Seirei Hamamatsu General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropathological features in Alzheimer's disease (AD) are amyloid β (Aβ) deposits and neurofibrillary changes. AD is characterized by memory impairment and cognitive dysfunction, with some reports associating these impairments with hyperexcitability caused by Aβ in the medial temporal lobe. Epileptic seizures are known to be common in AD. We encountered a 65-year-old patient with cavernous malformation (CM) in the right temporal lobe who exhibited epileptic amnesia (EA) and AD-like symptoms. Scalp electroencephalography (EEG), including long-term video-EEG, showed no interictal discharges, but intraoperative subdural electrode (SE) recording from the right parahippocampal area showed frequent epileptiform discharges. Neuropathologically, senile plaques were found in the surrounding normal cortex of the CM. Postoperatively, the patient has remained free of EA and AD-like symptoms since total removal of the CM. This is the first surgical case report to confirm temporal lobe hyperexcitability associated with EA and AD-like symptoms.

Indexed as

Alzheimer disease-like symptomsamyloid βcavernous malformationepileptic amnesiahyperexcitability of the medial temporal lobesubdural electrode recording

Identifiers

PMID31249550
PMCPMC6582224
OpenAlexW2949495431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.