Evidence map›Paper›PMID 31249525›Full record

ArticleFrontiers in pharmacology2019

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels.

Elsa Cortés-Montero, Pilar Sánchez-Blázquez, Yara Onetti, Manuel Merlos, Javier Garzón

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Article
  3. Article
  4. Article
  5. The Many Faces of Histidine Triad Nucleotide Binding Protein 1 (HINT1).ACS pharmacology & translational science · 2023
    Review
  6. Article
  7. Neuropathic pain: Mechanisms and therapeutic strategies.Frontiers in cell and developmental biology · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Steroids and TRP Channels: A Close Relationship.International journal of molecular sciences · 2020
    Review
  14. Partners in Crime: Towards New Ways of Targeting Calcium Channels.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elsa Cortés-MonteroNeuropharmacology, Department of Translational Neuroscience, Cajal Institute, CSIC, Madrid, Spain.
Pilar Sánchez-BlázquezNeuropharmacology, Department of Translational Neuroscience, Cajal Institute, CSIC, Madrid, Spain.
Yara OnettiNeuropharmacology, Department of Translational Neuroscience, Cajal Institute, CSIC, Madrid, Spain.
Manuel MerlosDrug Discovery & Preclinical Development, Esteve, Barcelona, Spain.
Javier GarzónNeuropharmacology, Department of Translational Neuroscience, Cajal Institute, CSIC, Madrid, Spain.
Instituto Cajal · ESEsteve Química (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sigma 1 receptor (σ1R) and the mu-opioid receptor (MOR) regulate the transient receptor potential (TRP) V1 calcium channel. A series of proteins are involved in the cross-regulation between MORs and calcium channels like the glutamate

Indexed as

calmodulinhistidine triad nucleotide-binding protein 1ligand biasN-methyl-D-aspartate receptortransient receptor potential ankyrin member 1transient receptor potential melastatin member 8transient receptor potential vanilloid member 1type 1 sigma receptor

Identifiers

PMID31249525
PMCPMC6582314
OpenAlexW2945362660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.