ReviewFrontiers in neuroscience2019
Canine Cognitive Dysfunction and Alzheimer's Disease - Two Facets of the Same Disease?
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
62 citing papers in PubMed, 132 citations in OpenAlex.
- Higher burden of neuropsychiatric symptom-like behaviors associated with canine cognitive dysfunction compared to normal aging in the Dog Aging Project.GeroScience · 2026Article
- The relationship between urinalysis abnormalities, soiling behavior, and cognitive decline in aging dogs.Journal of veterinary internal medicine · 2026Article
- Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration.Veterinary sciences · 2026Review
- Functional assessments of short-term spatial memory in the Dog Aging Project identify strong associations with age that are not moderated by body mass.GeroScience · 2026Article
- Untargeted plasma metabolomics in canine cognitive dysfunction: the naturally occurring Alzheimer's disease analog in dogs.Frontiers in neuroscience · 2026Article
- Thoracic limb stride length is associated with cognitive impairment in aging dogs.Frontiers in veterinary science · 2026Article
- Alzheimer's disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function.NPJ dementia · 2026Article
- Exploring behavioral outcomes of gonadectomy in pets: a need for personalized approaches.Animal reproduction · 2026Review
- Which aspects of the everyday behavior of older dogs correlate with performance on a visuo-spatial memory test and the canine cognitive dysfunction rating scale (CCDR)?Frontiers in aging neuroscience · 2026Article
- C16-siRNAs in Focus: Development of ALN-APP, a Promising RNAi-Based Therapeutic for Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The canine blood-brain barrier in health and disease: focus on brain protection.The veterinary quarterly · 2025Review
- Unveiling the significance of dog domestication in cognitive dysfunction: Are wolves protected?Open veterinary journal · 2025Article
- Plasma and cerebrospinal fluid biomarkers in aged dogs with cognitive decline.BMC veterinary research · 2025Article
- Diffusion tensor imaging analysis of aged dogs with and without canine cognitive dysfunction.BMC veterinary research · 2025Article
- One Health, Two Species: Linking Domestication to Cognitive Aging in Dogs and Humans.Animals : an open access journal from MDPI · 2025Article
- Functional assessments of short-term spatial memory in the Dog Aging Project identify strong associations with age that are not moderated by body mass.bioRxiv : the preprint server for biology · 2025Article
- The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Exosomal Non-Coding RNAs as Potential Biomarkers for Alzheimer's Disease: Advances and Perspectives in Translational Research.International journal of molecular sciences · 2025Review
- Diagnosis of Canine Cognitive Dysfunction Syndrome: A Narrative Review.Veterinary sciences · 2025Review
- Evaluation of Blood-Based Diagnostic Biomarkers for Canine Cognitive Dysfunction Syndrome.Animals : an open access journal from MDPI · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegenerative diseases present a major and increasing burden in the societies worldwide. With aging populations, the prevalence of neurodegenerative diseases is increasing, yet there are no effective cures and very few treatment options are available. Alzheimer's disease is one of the most prevalent neurodegenerative conditions and although the pathology is well studied, the pathogenesis of this debilitating illness is still poorly understood. This is, among other reasons, also due to the lack of good animal models as laboratory rodents do not develop spontaneous neurodegenerative diseases and human Alzheimer's disease is only partially mimicked by transgenic rodent models. On the other hand, older dogs commonly develop canine cognitive dysfunction, a disease that is similar to Alzheimer's disease in many aspects. Dogs show cognitive deficits that could be paralleled to human symptoms such as disorientation, memory loss, changes in behavior, and in their brains, beta amyloid plaques are commonly detected both in extracellular space as senile plaques and around the blood vessels. Dogs could be therefore potentially a very good model for studying pathological process and novel treatment options for Alzheimer's disease. In the present article, we will review the current knowledge about the pathogenesis of canine cognitive dysfunction, its similarities and dissimilarities with Alzheimer's disease, and developments of novel treatments for these two diseases with a focus on canine cognitive dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.