Evidence map›Paper›PMID 31249490›Full record

ReviewThe Yale journal of biology and medicine2019

Do Disruptions in the Circadian Timing System Contribute to Autonomic Dysfunction in Huntington's Disease?

Saemi Park, Christopher S Colwell

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in The Yale journal of biology and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Systemic Symptoms in Huntington's Disease: A Comprehensive Review.Movement disorders clinical practice · 2024
    Pooled it
  2. Review
  3. Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025
    Review
  4. Review
  5. Heart rate variability and falls in Huntington's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Saemi ParkMolecular, Cellular and Integrative Physiology graduate program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Christopher S ColwellMolecular, Cellular and Integrative Physiology graduate program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) patients suffer from a progressive neurodegenerative disorder that inflicts both motor and non-motor symptoms. HD is caused by a CAG repeat expansion within the first exon of the

Indexed as

AnimalsCircadian ClocksCircadian RhythmHumansHuntington DiseaseHypothalamus, AnteriorModels, BiologicalNeurodegenerative DiseasesPrimary DysautonomiasTime Factorsautonomic nervous systemcardiovascular diseasecircadiandysautonomiaHuntington’s diseaseneurodegenerative diseasesleep

Identifiers

PMID31249490
PMCPMC6585531
OpenAlexW2982695853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.