Evidence map›Paper›PMID 31249484›Full record

ReviewThe Yale journal of biology and medicine2019

Retinal Circadian Clocks are Major Players in the Modulation of Retinal Functions and Photoreceptor Viability.

Christopher DeVera, Kenkichi Baba, Gianluca Tosini

Abstract readReview
In one paragraph

Review in The Yale journal of biology and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. iScience · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Real-Time Monitoring of Circadian Rhythms in the Eye.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  12. Photoreceptor Degeneration in Homozygous Male Per2Journal of biological rhythms · 2021
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher DeVeraDepartment of Pharmacology & Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Kenkichi BabaDepartment of Pharmacology & Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Gianluca TosiniDepartment of Pharmacology & Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian rhythms control many biochemical and physiological functions within the body of an organism. These circadian rhythms are generated by a molecular clock that is located in almost every cell of the body. Accumulating data indicate that dysfunction of the circadian clock negatively affects the health status of the tissue in which the circadian clock has been disabled. The eye also contains a complex circadian system that regulates many important functions such as the processing of light information, the release of neurotransmitters, and phagocytic activity by the retinal pigment epithelium, to name just a few. Emerging experimental evidence indicates that dysfunction of the circadian clock within the retina has severe consequence for retinal function and photoreceptor viability. The aim of this review is to provide the reader with a summary of current knowledge about the eye circadian system and what effects emerge with a disruption of this system.

Indexed as

AnimalsCircadian ClocksCircadian RhythmCLOCK ProteinsGene Expression RegulationHumansModels, BiologicalPhotoreceptor Cells, VertebrateRetinaCLOCK ProteinsBmal1circadian clockcornearetinaRPE

Identifiers

PMID31249484
PMCPMC6585523

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.