What is Phase in Cellular Clocks?

Cristian Caranica, Jia H Cheong, Xiao Qiu, Emily K Krach, Zhaojie Deng, Leidong Mao, H-Bernd Schüttler, Jonathan Arnold

Abstract read

In one paragraph

Article in The Yale journal of biology and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Origin of the clock inFrontiers in molecular biosciences · 2025
Review
The clock in growing hyphae and their synchronization in Neurospora crassa.Communications biology · 2024
Article
The macroscopic limit to synchronization of cellular clocks in single cells of Neurospora crassa.Scientific reports · 2022
Article
Synchronization between peripheral circadian clock and feeding-fasting cycles in microfluidic device sustains oscillatory pattern of transcriptome.Nature communications · 2021
Article
Dissociation of the G protein βγ from the Gq-PLCβ complex partially attenuates PIP2 hydrolysis.The Journal of biological chemistry
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristian CaranicaDepartment of Statistics, University of Georgia, Athens, GA.

Jia H CheongSchool of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA.

Xiao QiuInstitute of Bioinformatics, University of Georgia, Athens, GA.

Emily K KrachGenetics Department, University of Georgia, Athens, GA.

Zhaojie DengDepartment of Genome Sciences, University of Washington, Seattle, WA.

Leidong MaoSchool of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA.

H-Bernd SchüttlerDepartment of Physics and Astronomy, University of Georgia, Athens, GA.

Jonathan ArnoldGenetics Department, University of Georgia, Athens, GA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Four inter-related measures of phase are described to study the phase synchronization of cellular oscillators, and computation of these measures is described and illustrated on single cell fluorescence data from the model filamentous fungus,

Indexed as

AlgorithmsBiological ClocksCircadian ClocksCircadian RhythmFungal ProteinsGene Expression Regulation, FungalLuminescent MeasurementsModels, BiologicalNeurospora crassaSingle-Cell AnalysisStochastic ProcessesTime FactorsFungal Proteinscircadian rhythmsHilbert PhaseNeurospora crassaphasesingle cell measurementssynchronization

Identifiers

PMID31249477

PMCPMC6585513

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.