Evidence map›Paper›PMID 31249422›Full record

ReviewNature methods2019

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Glenn R Masson, John E Burke, Natalie G Ahn, Ganesh S Anand, Christoph Borchers, Sébastien Brier, George M Bou-Assaf, John R Engen, S Walter Englander, Johan Faber and 30 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 419 papers.

0numbers the graph read from it
0cells of the map it votes in
419citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

419 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Modulating pseudokinase conformation from the ATP-binding site.Structure (London, England : 1993) · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

359 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Glenn R MassonMRC Laboratory of Molecular Biology, Cambridge, UK. gmasson@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0002-1386-4719
John E BurkeDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada. jeburke@uvic.ca.ORCID http://orcid.org/0000-0001-7904-9859
Natalie G AhnDepartment of Biochemistry, University of Colorado, Boulder, CO, USA.
Ganesh S AnandDepartment of Biological Science, National University of Singapore, Singapore, Singapore.
Christoph BorchersGenome BC Proteomics Centre, University of Victoria, Victoria, BC, Canada.
Sébastien BrierInstitut Pasteur, Chemistry and Structural Biology Department, Paris, France.
George M Bou-AssafBiogen Idec, Cambridge, MA, USA.
John R EngenDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6918-9476
S Walter EnglanderDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Johan FaberNovo Nordisk, Måløv, Denmark.
Rachel GarlishUCB Celltech, Slough, UK.
Patrick R GriffinDepartment of Integrative Structural and Computational Biology, Scripps Florida, The Scripps Research Institute, Jupiter, FL, USA.
Michael L GrossDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-1159-4636
Miklos GuttmanDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA.
Yoshitomo HamuroJohnson & Johnson Pharmaeutical Research and Development, Jersey City, NJ, USA.
Albert J R HeckBijvoet Center for Biomolecular Research, Utrecht University, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-2405-4404
Damian HoudeCodiak Biosciences, Cambridge, MA, USA.
Roxana E IacobDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6106-4698
Thomas J D JørgensenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej, Odense, Denmark.
Igor A KaltashovDepartment of Chemistry, University of Massachusetts-Amherst, Amherst, MA, USA.
Judith P KlinmanDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-5734-2843
Lars KonermannDepartment of Chemistry, The University of Western Ontario, London, ON, Canada.
Petr ManInstitute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
Leland MayneDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Bruce D PascalDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
Dana ReichmannDepartment of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0003-0315-5334
Mark SkehelMRC Laboratory of Molecular Biology, Cambridge, UK.
Joost SnijderDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA.
Timothy S StrutzenbergDepartment of Integrative Structural and Computational Biology, Scripps Florida, The Scripps Research Institute, Jupiter, FL, USA.ORCID http://orcid.org/0000-0003-0598-534X
Eric S UnderbakkeRoy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.ORCID http://orcid.org/0000-0003-4269-7339
Cornelia WagnerRoche Innovation Center Penzberg, Penzberg, Germany.
Thomas E WalesDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
Benjamin T WaltersDepartment of Early Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA, USA.
David D WeisDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA.ORCID http://orcid.org/0000-0003-3032-1211
Derek J WilsonDepartment of Chemistry, York University, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-7012-6085
Patrick L WintrodeDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Zhongqi ZhangProcess Development, Amgen, Thousand Oaks, CA, USA.
Jie ZhengDepartment of Integrative Structural and Computational Biology, Scripps Florida, The Scripps Research Institute, Jupiter, FL, USA.
David C SchriemerDepartment of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, Canada. dschriem@ucalgary.ca.ORCID http://orcid.org/0000-0002-5202-1618
Kasper D RandDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark. kasper.rand@sund.ku.dk.ORCID http://orcid.org/0000-0002-6337-5489

Funding

Looking in New Directions for Origins and Cryptic Mechanisms of Enzyme CatalysisR35GM118117 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KLINMAN, JUDITH P · 2016 to 2025
$7.5M
Medical Research Council MC_U105184308NIGMS NIH HHS R35 GM118117
6 · The paper itself

Abstract

Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhance the accessibility of this technique to nonspecialists. Here we provide recommendations arising from community discussions emerging out of the first International Conference on Hydrogen-Exchange Mass Spectrometry (IC-HDX; 2017). It is meant to represent both a consensus viewpoint and an opportunity to stimulate further additions and refinements as the field advances.

Indexed as

Data AnalysisDeuterium Exchange MeasurementHydrogen-Ion ConcentrationMass Spectrometry

Identifiers

PMID31249422
PMCPMC6614034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.