ArticleNature communications2019
Intrinsic enzymatic properties modulate the self-propulsion of micromotors.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 173 citations in OpenAlex.
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- Synergistic magneto-enzymatic propulsion enables multimodal nanomotor swarms.Nature communications · 2026Article
- The Application of Micro/Nanorobots in Cancer Therapy.Micromachines · 2026Review
- SERS-Based Nano- and Microsystems Toward Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Endogenous ATP-powered nanomotors directing neural stem cell differentiation for Parkinson's disease treatment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Programmable Nanoscale Motion via Molecular Patterning on DNA Origami.Angewandte Chemie (International ed. in English) · 2026Article
- Glucose-Powered Ultrasmall Chemotactic Nanorobots for Retinal Degeneration Treatment.Journal of the American Chemical Society · 2025Article
- Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A roadmap for next-generation nanomotors.Nature nanotechnology · 2025Review
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Nanorobot-Cell Communication viaACS nano · 2025Article
- Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair.ACS nano · 2025Article
- Chemotactic Zn micromotor for treatment of high blood ammonia-associated hepatic encephalopathy.Nature communications · 2025Article
- Hyaluronic Acid-Based Nanomotors: Crossing Mucosal Barriers to Tackle Antimicrobial Resistance.ACS applied materials & interfaces · 2025Article
- Progress in enzyme-powered micro/nanomotors in diagnostics and therapeutics.Bioactive materials · 2025Review
- Urease-powered micro/nanomotors: Current progress and challenges.Journal of pharmaceutical analysis · 2025Review
- Collective buoyancy-driven dynamics in swarming enzymatic nanomotors.Nature communications · 2024Article
- Swarms of Enzymatic Nanobots for Efficient Gene Delivery.ACS applied materials & interfaces · 2024Article
- Mechanistic insights into condensate formation of human liver-type phosphofructokinase by stochastic modeling approaches.Scientific reports · 2024Article
- Microgripper Robot with End Electropermanent Magnet Collaborative Actuation.Micromachines · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bio-catalytic micro- and nanomotors self-propel by the enzymatic conversion of substrates into products. Despite the advances in the field, the fundamental aspects underlying enzyme-powered self-propulsion have rarely been studied. In this work, we select four enzymes (urease, acetylcholinesterase, glucose oxidase, and aldolase) to be attached on silica microcapsules and study how their turnover number and conformational dynamics affect the self-propulsion, combining both an experimental and molecular dynamics simulations approach. Urease and acetylcholinesterase, the enzymes with higher catalytic rates, are the only enzymes capable of producing active motion. Molecular dynamics simulations reveal that urease and acetylcholinesterase display the highest degree of flexibility near the active site, which could play a role on the catalytic process. We experimentally assess this hypothesis for urease micromotors through competitive inhibition (acetohydroxamic acid) and increasing enzyme rigidity (β-mercaptoethanol). We conclude that the conformational changes are a precondition of urease catalysis, which is essential to generate self-propulsion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.