ArticleScientific reports2019
Validation of the Fetal Lamb Model of Spina Bifida.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta-analysis.Prenatal diagnosis · 2021Pooled it
- Novel Fetal Embolization Technique via Transcardiac Transarterial Ultrasound- and Fluoroscopy-Guided Endovascular Surgery for Vein of Galen Malformation: Preclinical Study in the Fetal Lamb.Prenatal diagnosis · 2026Article
- Impact of Fetoscopic Surgery on the Myometrium: Experimental Study in an Ovine Model of Myelomeningocele.Prenatal diagnosis · 2026Article
- Germline and Embryonic Mechanisms in the Epigenetic Inheritance of Neurodevelopmental and Cognitive Traits in Mammals.Biomolecules · 2026Review
- The Ovine Brain as a Model for Human Neurodevelopment: Immunohistochemical Profiling of Brain Maturation Markers in Preterm Lambs.The Journal of comparative neurology · 2026Article
- A filamentary soft robotic probe for multimodal in utero monitoring of fetal health.Nature biomedical engineering · 2026Article
- Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Gait analysis in swine, sheep, and goats after neurologic injury: a literature review.Neural regeneration research · 2023Review
- Fetal Surgery for Myelomeningocele: Neurosurgical Perspectives.Advances and technical standards in neurosurgery · 2023Article
- The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders.Biology · 2022Review
- Early investigations into improving bowel and bladder function in fetal ovine myelomeningocele repair.Journal of pediatric surgery · 2022Article
- Allografts for Skin Closure during In Utero Spina Bifida Repair in a Sheep Model.Journal of clinical medicine · 2021Article
- A preliminary investigation of high retinoic acid exposure during fetal development on behavioral competency and litter characteristics in newborn rats.Brain and behavior · 2021Article
- Validation of a high-fidelity training model for fetoscopic spina bifida surgery.Scientific reports · 2021Article
- Effects of Maternal Abdominal Surgery on Fetal Brain Development in the Rabbit Model.Fetal diagnosis and therapy · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
A randomized trial demonstrated that fetal spina bifida (SB) repair is safe and effective yet invasive. New less invasive techniques are proposed but are not supported by adequate experimental studies. A validated animal model is needed to bridge the translational gap to the clinic and should mimic the human condition. Introducing a standardized method, we comprehensively and reliably characterize the SB phenotype in two lamb surgical models with and without myelotomy as compared to normal lambs. Hindbrain herniation measured on brain magnetic resonance imaging (MRI) was the primary outcome. Secondary outcomes included gross examination with cerebrospinal fluid (CSF) leakage test, neurological examination with locomotor assessment, whole-body MRI, motor and somatosensory evoked potentials; brain, spinal cord, hindlimb muscles, bladder and rectum histology and/or immunohistochemistry. We show that the myelotomy model best phenocopies the anatomy, etiopathophysiology and symptomatology of non-cystic SB. This encompasses hindbrain herniation, ventriculomegaly, posterior fossa anomalies, loss of brain neurons; lumbar CSF leakage, hindlimb somatosensory-motor deficit with absence of motor and somatosensory evoked potentials due to loss of spinal cord neurons, astroglial cells and myelin; urinary incontinence. This model obtains the highest validity score for SB animal models and is adequate to assess the efficacy of novel fetal therapies.
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Registered trials
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