ArticleScientific reports2019
Lineage tracing analysis of cone photoreceptor associated cis-regulatory elements in the developing chicken retina.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids.Genes & development · 2026Article
- Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.Endocrinology · 2023Article
- Transcriptomic analysis reveals the dynamic changes of transcription factors during early development of chicken embryo.BMC genomics · 2022Article
- Cell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis.International journal of molecular sciences · 2022Article
- An enhancer located in a Pde6c intron drives transient expression in the cone photoreceptors of developing mouse and human retinas.Developmental biology · 2022Article
- Visualizing Cortical Development and Evolution: A Toolkit Update.Frontiers in neuroscience · 2022Review
- Early cis-regulatory events in the formation of retinal horizontal cells.Developmental biology · 2021Article
- Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states.Scientific reports · 2021Article
- A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation.iScience · 2021Article
- Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors.Development (Cambridge, England) · 2021Article
- Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch.Neuron · 2020Article
- OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification.eLife · 2020Article
- Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells.Neural development · 2020Article
- Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
During vertebrate retinal development, transient populations of retinal progenitor cells with restricted cell fate choices are formed. One of these progenitor populations expresses the Thrb gene and can be identified by activity of the ThrbCRM1 cis-regulatory element. Short-term assays have concluded that these cells preferentially generate cone photoreceptors and horizontal cells, however developmental timing has precluded an extensive cell type characterization of their progeny. Here we describe the development and validation of a recombinase-based lineage tracing system for the chicken embryo to further characterize the lineage of these cells. The ThrbCRM1 element was found to preferentially form photoreceptors and horizontal cells, as well as a small number of retinal ganglion cells. The photoreceptor cell progeny are exclusively cone photoreceptors and not rod photoreceptors, confirming that ThrbCRM1 progenitor cells are restricted from the rod fate. In addition, specific subtypes of horizontal cells and retinal ganglion cells were overrepresented, suggesting that ThrbCRM1 progenitor cells are not only restricted for cell type, but for cell subtype as well.
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