ArticleScientific reports2019
Efficient Grafting of Cyclodextrin to Alginate and Performance of the Hydrogel for Release of Model Drug.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Engineering alginate hydrogels loaded with resveratrol as a dual platform for cancer therapy and wound regeneration.Discover nano · 2026Review
- Cyclodextrin-Grafted Polysaccharides as Sustainable Platforms for Biomedical and Environmental Applications.International journal of molecular sciences · 2026Review
- Cyclodextrin-Based Strategies for Brain Drug Delivery: Mechanistic Insights into Blood-Brain Barrier Transport and Therapeutic Applications.Pharmaceutics · 2026Review
- Biologically Active Molecules from Marine Brown Algae: A Review of Their Potential and Applications.Chemistry & biodiversity · 2026Review
- A versatile and efficient method to quantify purity and degree of substitution in alginate derivatives.Carbohydrate polymers · 2025Article
- Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration.Bioactive materials · 2025Review
- Advances in Cyclodextrins and Their Derivatives in Nano-Delivery Systems.Pharmaceutics · 2024Review
- Rheological and Self-Healing Behavior of Hydrogels Synthesized from l-Lysine-Functionalized Alginate Dialdehyde.Polymers · 2023Article
- Clickable Polysaccharides for Biomedical Applications: A Comprehensive Review.Progress in polymer science · 2022Article
- Novel Chemical Architectures Based on Beta-Cyclodextrin Derivatives Covalently Attached on Polymer Spheres.Polymers · 2021Article
- From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances.International journal of molecular sciences · 2021Review
- Alginate and alginate composites for biomedical applications.Asian journal of pharmaceutical sciences · 2021Review
- Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications.Molecules (Basel, Switzerland) · 2020Review
- Mechanical Properties of Ca-Saturated Hydrogels with Functionalized Alginate.Gels (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlling the rate of release of molecules from a hydrogel is of high interest for various drug delivery systems and medical devices. A strategy to alter the release profiles of soluble and poorly soluble active ingredients from hydrogels can be to combine the hydrogel forming ability of alginate with the inclusion forming ability of cyclodextrins (CyD). Here, β-CyD was grafted to alginate in a three-step synthesis using periodate oxidation, reductive amination and copper(I)-catalyzed azide-alkyne cycloaddition. A grafting degree of 4.7% mol β-CyD/mol sugar residues was obtained. The grafting degree was controlled by varying the reaction parameters where the amount of linker used in reductive amination was especially influential. Ca-alginate gel beads grafted with β-CyD showed increased uptake of the model molecule methyl orange. Release experiments showed that the grafted material had a prolonged release of methyl orange and an increased total amount of released methyl orange. These results show that the β-CyD grafted alginate is still able to form a hydrogel while the grafted cyclodextrins retain their ability to form inclusion complex with methyl orange. Further testing should be done with this system to investigate capability for drug delivery applications.
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Registered trials
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